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EC number: 430-550-0 | CAS number: 1671-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 February - 28 October 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, no restrictions, fully adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 430-550-0
- EC Name:
- -
- Cas Number:
- 1671-49-4
- Molecular formula:
- C8H9NO4S
- IUPAC Name:
- 4-methanesulfonyl-1-methyl-2-nitrobenzene
- Details on test material:
- - Physical state: off-white powder
- Purity test date: 25 July 2005
- Expiration date of the lot/batch: July 2006
- Storage condition of test material: <30°C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alpk:APfSD (Wistar-derived)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: approximately 8 weeks
- Weight at study initiation: 345±16.6 g (males), 240.8±12.3 g (females)
- Fasting period before study: none
- Housing: 5 per cage, sexes separately in cages suitable for rats of this strain and weight range expected during the course of the study
- Diet: RMI ad libitum (except during exposure)
- Water: mains water ad libitum (except during exposure)
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22±3°C
- Humidity: 30-70%
- Air changes: minimum of 15 per hr
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: From: 14 October 2005 To: 28 October 2005
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: PERSPEX exposure chamber covered with an aluminium cone and standing on an aluminium base
- Exposure chamber volume: approximately 9.2 L (in this study 2 chambers were connected giving a total chamber volume of approximately 27.6 L)
- Method of holding animals in test chamber: polycarbonate restraining tubes
- Source and rate of air: clean, dried and filtered air, at least 10 air-changes per hour. Flow rates 20 L/min.
- System of generating particulates/aerosols: Rotating Brush Generator (RBG)
- Method of particle size determination: Marple Cascade Impactor
- Temperature, humidity, pressure in air chamber: 21.2-21.3°C; 5-7%, slightly higher than ambient
TEST ATMOSPHERE
- Brief description of analytical method used: HPLC
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observed prior to study start, frequently during exposure, at end of exposure period and once per day thereafter. Weighed prior to study start (day -1), days 1, 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: none - Statistics:
- None (limit test, no mortalities)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.41 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: limit test, no mortalities
- Mortality:
- none
- Clinical signs:
- other: During exposure, abnormalities generally associated with restraint (wet fur and chromodacryorrhea) were seen and all animals had substance around the snout. Immediately after exposure wet fur, salivation, stains around the nose and chromodacryorrhea were
- Body weight:
- All animals gained weight by day 8 and continued to gain weight until the end of the study.
- Gross pathology:
- No abnormalities were seen.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Nose-only exposure for 4 hours to a particulate concentration of 5.41 mg/L of the test substance resulted in no deaths and no adverse effects. The acute inhalation LC50 is in excess of 5.41 mg/L.
- Executive summary:
A group of 5 male and 5 female Alpk:APfSD (Wistar-derived) rats were exposed nose-only for a single 4-hour period to the test substance at a target particulate concentration of 5 mg/L. Test atmospheres were analysed for particulate concentration and the test substance. Following exposure, the animals were retained for 14 days without treatment. Clinical observations and bodyweights were recorded throughout the study and at the end of the scheduled period the animals were killed and subjected to a gross examination post mortem. The achieved test atmosphere had the following characteristics: achieved particulate concentration = 5.41 mg/L; MMAD 7.02 and 6.06 µm; GSD 1.77 and 1.74. Nose-only exposure for 4-hours to a particulate concentration of 5.41 mg/L resulted in no deaths and no adverse effects. The acute inhalation LC50is in excess of 5.41 mg/L.
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