Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-460-0 | CAS number: 2439-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the key studies for skin and eye irritation the test substance is considered to be corrosive to the skin (BASF AG, 1982) and highly irritating to the eye (BASF AG, 1979). The substance may be (highly) irritating to the respiratory tract.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation/corrosion:
There are four reports available. Among them, the study by BASF AG (1982) was identified as the key study because it was conducted according to OECD TG 404. In this study, the undiluted test substance was applied to the intact skin of six New-Zealand White rabbits at a dose level of 0.5 ml per animal under semiocclusive and occlusive conditions for 3 minutes, 1 hour or 4 hours. According to the cutaneous reactions 24, 48 and 72 hours after the 4-hours exposure under semiocclusive conditions the test substance is considered to be corrosive to the skin.
The other studies, that were all performed in rabbits, do not provide additional information on the skin irritation/corrosion potential because according to all reports the test substance is considered to be corrosive to the skin (Potokar et al., 1984; BASF AG, 1979; Atochem, 1981).
Eye irritation:
There are two reports available. The study by BASF AG (1979) was identified as the key study because it was conducted according to the recommendations of the Federal Register 38, No. 187, § 1500.41, p. 27019 from 27 Sep. 1973. The irritant/corrosive response data in the eyes of three Vienna White rabbits after application of 0.1 ml undiluted test substance were not fully reversible within 8 days. The test substance is considered to be highly irritating to the eye.
In the second study by Atochem (1981), severe cornea, iris and conjunctivae lesions were displayed in all two rabbits within 1 hour after the instillation of 0.1 ml undiluted substance that was removed by washing 4 seconds after application. Although the test was terminated after 1 hour on humane grounds, it is reasonable to assume that similar levels of injury would be produced if full scale testing were conducted, and that the test substance would be classified as severly irritating or corrosive to the eye.
Respiratory irritation:
There exists no standard test method for the assessment of respiratory irritation. There is some evidence from several inhalation hazard tests that 2-(dimethylamino)ethyl acrylate vapour and aerosol may be irritating to the nose, eyes and respiratory tract of rats (BASF AG 1979, Atochem 1991). Since the substance is classified as corrosive, the potential to cause respiratory tract irritation is implicitly covered.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: highly irritating
Justification for classification or non-classification
EU classification according to Annex VI of the Directive 67/548/EEC:
- Skin irritation/corrosion: Causes burns, R34
- Eye irritation: Results from eye irritation studies fulfill the criteria for assignment of the risk phrase "Risk of serious eye damage (R41)". However, since the substance is classified as corrosive and assigned R34, the risk of severe damage to eyes is considered implicit and R41 is not included in the label.
- Respiratory irritation:
Since the substance is classified as corrosive, the potential to cause respiratory tract irritation is implicitly covered.
GHS classification according toAnnex I 1272/2008 CLP (EU GHS):
- Skin irritation/corrosion Cat. 1B
- Respiratory irritation: Since the substance is classified as corrosive, the potential to cause respiratory tract irritation is implicitly covered.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.