Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 270-601-2 | CAS number: 68457-13-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- other: Any kind of reliability rating is not considered to be applicable, since human health surveillance data, epidemiological studies, field studies and case reports are not conducted/reported according to standardised guidelines
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The references contained in this summary entry represent monitoring data of the general population with very limited value for risk assessment purposes, due to the following reasons. The reported data suffer either from a lack of statistical relevance (low number of samples), inadequacy of the analytical method or lack plausibility; not considered relevant or reliable for risk assessment purposes.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Essential trace metal in man: Cobalt
- Author:
- Schroeder, H. A. et al.
- Year:
- 1 967
- Bibliographic source:
- J. Chronic Dis. 20, 869-890
- Reference Type:
- publication
- Title:
- Metal concentrations in human lung tissue, with special references to age, sex, cause of death, emphysema and contamination of lung tissue
- Author:
- Takemoto, K. et al.
- Year:
- 1 991
- Bibliographic source:
- Int. Arch. Occup. Environ. Health 62, 579-586
- Reference Type:
- publication
- Title:
- Trace elements in human tissue, Part II. Adult subjects from the United States
- Author:
- Tipton, I.H.; Cook, M.
- Year:
- 1 963
- Bibliographic source:
- Health Phys. 9, 103-145
- Reference Type:
- publication
- Title:
- The Cobalt Content of Human Body
- Author:
- Yamagata, N.
- Year:
- 1 962
- Bibliographic source:
- J. Radiat. Res. 3, 4-8
Materials and methods
- Study type:
- other: monitoring
- Endpoint addressed:
- basic toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- STUDY 1:“normal” background cobalt tissue levels in human autopsy material from non-exposed individuals STUDY 2:Analysis of cobalt concentrations in 1,438 human lung autopsy samples from JapanSTUDY 3:Analysi of cobalt as a trace element as "background" in human tissue samples from spontaneously deceased individuals (n=150)STUDY 4:Normal background cobalt tissue levels in human autopsy samples (n=14)
- GLP compliance:
- no
Test material
- Reference substance name:
- Cobalt
- EC Number:
- 231-158-0
- EC Name:
- Cobalt
- Cas Number:
- 7440-48-4
- Molecular formula:
- Co
- IUPAC Name:
- cobalt(2+)
Constituent 1
Method
- Type of population:
- general
- Details on study design:
- STUDY 1: Foods, feeds and human tissue from three autopsies were analysed for cobalt by atomic absorption spectrophotometry.STUDY 2: Cobalt was analysed in lung tissue from autopsy samples of individuals, who had suffered from a wide range of illnesses, by atomic absorption spectrometry. STUDY 3: Tissue samples of 150 subjects were collected, prepared and spectrographical and statistical analysed for 27 variables.STUDY 4: Spectrophotometric analyses have been made of common cobalt in the human tissue and organs from autopsies.
Results and discussion
- Results:
- STUDY 1:Cobalt was analysed in three autopsy samples from the US with concentrations ranging from 0.01-0.4 ug/g (wet weight). In samples from a total of 348 subjects from both the US and abroad, cobalt levels were close to or below detection limit.STUDY 2:Cobalt was analysed in lung tissue from individuals who had suffered from a wide range of illnesses. Median lung cobalt levels were 0.18 ug/g (dry weight), with a 95th percentile of 0.9 ug/g. Cobalt levels did not vary with age, sex or severity of lung emphysema, for example.STUDY 3:Cobalt was analysed in a wide range of tissues, but was below detection limit in all cases, due to a lack in sensitivity of the analytical method.STUDY 4:The authors claim that cobalt was detected in autopsy samples from Japan at concentrations ranging from 1-77 ug/g (wet weight), with highest concentrations in bone. These data are not plausible, since they are three orders of magnitude higher than other published data (which are reported in ug/g).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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