Registration Dossier
Registration Dossier
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EC number: 214-254-7 | CAS number: 1117-86-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The water/octanol partition coefficient log Pow of 2.1, the moderately high water solubility of 7.5 g/L and the low molecular weight are favouring absorption of octane-1,2-diol. However, based on these properties bioaccumulation is rather unlikely
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of octane-1,2-diol.
Absorption and systemic availability of octane-1,2-diol or metabolites after oral administration has been concluded from its moderately high water solubility (7.5 g/L at 20°C), partition coefficient (Log10Pow = 2.1), its relatively low molecular weight (146) and the finding of slightly reduced locomotor activity in rats treated in a 28-day oral (gavage) toxicity study at 1000 mg/kg bw/day. The three physicochemical properties also favour dermal uptake, although the systemic availability of octane-1,2-diol after dermal uptake is considered to be lower than after gastro-intestinal absorption.
The partition coefficient Pow and the moderately high water solubility of octane-1,2-diol favour absorption directly across the respiratory tract epithelium by passive diffusion. However, the risk of exposure by the inhalation route is considered to be low, because of its relatively low vapour pressure (0.28 Pa at 25°C, 0.15 Pa at 20°C).
All available experimental study results gave no indication regarding the metabolic pathway, distribution or excretion of octane-1,2-diol itself, but for the structural substance analogue, butane-1,2-diol (EC 209-527-2), excretion in the urine as its glucuronide or unchanged was demonstrated after i.v. infusion to the rabbit. Based on metabolism modelling on C6-, C8-, C10- and C12 alkane-1,2-diols С-oxidation, C-hydroxylation, glucuronidation and beta-oxidation were identified as possible pathways for forming corresponding metabolites, whereby hydroxylation and beta-oxidation are more likely to be favoured for the metabolic pathways of the latter two substance analogues.
Bioaccumulation was not investigated, but in view of its Log10Pow of 2.1, octane-1,2-diol is not considered to be bioaccumulative.
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