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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 201-176-3 | CAS number: 79-09-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No definitive skin sensitization studies have been conducted for propionic acid.
Occupational sensitization has not been reported among workers (OECD SIDS for SIAM 25, 2007). There was no sensitization response to sodium propionate in trials with human subjects following topical use (Haseltine, 1952). However, positive pin-prick responses to propionic acid were obtained in 3/91 patients suffering from chronic uticaria: patients were presumed to have prior
exposure with propionic acid as a food preservative. There was no response observed among 247 normal control (non-uticaria) subjects (Malanin, and Kalimo, 1989)
In a dermal sensitization study with calcium propionate (CAS No. 4075-81-4) in water (intradermal induction) and Vaseline (topical induction and challenge), young guinea pigs were tested according to the method described by Magnusson and Kligmann (1970), a method comparable OECD TG 406. The control group contained 10 animals and 6 guinea pigs were used in the test group. Intradermal inductions were performed with 2% of calcium propionate in water while topical inductions were carried out with 20% calcium propionate in Vaseline, 1 week later and under occlusive conditions for 48 hours. 2 weeks after topical induction exposure, challenge was performed epicutaneously (open) with 20% calcium propionate in Vaseline. No positive control was tested. No skin irritations were noticed in all animals of the control or treated group after challenge experiments (TNO/CIVO 1978). In this study, calcium propionate is not a dermal sensitizer.
The same authors tested the sensitization potential of sodium propionate (CAS No.137-40-6) in young guinea pigs following an identical study design and concentrations described for calcium propionate (TNA/CIVO 1978). In this study, sodium propionate is not a dermal sensitizer
Migrated from Short description of key information:
Salts of propionic acid are not skin sensitizing in animal tests. Thus, propionic acid is not considered to be sensitizing to the skin.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
No data for the assessment of respiratory sensitization are available. As propionic acid is not supposed to be sensitizing to the skin it is also not supposed to be sensitizing to the respiratory tract.
Justification for classification or non-classification
Classification is not warranted according to the criteria of EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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