Registration Dossier
Registration Dossier
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EC number: 200-273-8 | CAS number: 56-41-7
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
Data source
Reference
- Reference Type:
- publication
- Title:
- Amino acids from chemical group 34 Flavouring Group Evaluation 26, Revision 1 Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) (Question No EFSA-Q-2003-169B)
- Author:
- EFSA
- Year:
- 2 008
- Bibliographic source:
- EFSA Journal (2008), 790: 1-51
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The effects at the high dose of 3850 mg/kg bw consisted of reduced maternal body weight gain and reduced fetal weight and length which is likely to be a nutritional rather than a toxicological effect. The maternal and fetal NOAEL were set at the lower dose of 15.6 g/kg diet (equivalent to 780 mg/kg bw/day).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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