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Diss Factsheets
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EC number: 258-469-4 | CAS number: 53306-54-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Levels of phthalate metabolites in urine among mother–child-pairs – Results from the Duisburg birth cohort study, Germany
- Author:
- Monika Kasper-Sonnenberg et al.
- Year:
- 2 012
- Bibliographic source:
- International Journal of Hygiene and Environmental Health 215 (2012) 373–382
Materials and methods
- Study type:
- cross sectional study
- Principles of method if other than guideline:
- DPHP metabolites (6-OH-Mono-propyl-heptyl phthalate, 6-Oxo-Mono-propyl-heptyl phthalate, and Mono-(2,7-methyl-7-carboxy-heptyl) phthalate) were determined in urine by multidimensional liquid chromatography coupled to tandem mass spectrometry using internal isotope-labeled standards. The LOQ was 0.2µg/L. These metabolites could not be distinguished from the isomeric metabolites that originated from Di-iso-decylphthalate (DIDP).
To prevend "dilution effects", urine samples with creatinine values below 0.3 and above 3g creatinine/L were excluded from further analysis. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Bis(2-propylheptyl) phthalate
- EC Number:
- 258-469-4
- EC Name:
- Bis(2-propylheptyl) phthalate
- Cas Number:
- 53306-54-0
- Molecular formula:
- C28H46O4
- IUPAC Name:
- 1,2-bis(2-propylheptyl) benzene-1,2-dicarboxylate
Constituent 1
Method
- Type of population:
- other: mother-child pairs
- Ethical approval:
- confirmed and informed consent free of coercion received
- Details on study design:
- METHOD OF DATA COLLECTION
- Type: Urine samples
- Details: First morning urine samples from 104 mother-child pairs
STUDY PERIOD: October 2007 to February 2009
STUDY POPULATION
- Selection criteria: self-selected (for previous study in 2000) and responded to follow up letter
- Total number of subjects participating in study: 104 mother-child pairs
- Age children: 6.8 years on average
- Age mothers: 39.2 years on average
- Smoker/nonsmoker: identifed via cotinine and 3OH-cotinine concentration in urine - Exposure assessment:
- measured
- Statistical methods:
- For statistical analyses volume-based concentrations of the measured chemicals and sum values of selected metabolites were used. Values below the LOQ were set to ½ of the LOQ for further calculations.
Results and discussion
- Results:
- Children:
6-OH-Mono-propyl-heptyl phthalate (OH-MiDP): detected in 97% of the samples, Geometric mean: 2.1µg/L (max value: 63.8µg/L)
6-Oxo-Mono-propyl-heptyl phthalate (oxo-MiDP): detected in 95% of the samples, Geometric mean: 0.6µg/L (max value: 19.2µg/L)
Mono-(2,7-methyl-7-carboxy-heptyl) phthalate (cx-MiDP): detected in all samples, Geometric mean: 1.3µg/L (max value 45.3µg/L)
Mothers:
6-OH-Mono-propyl-heptyl phthalate (OH-MiDP): detected in 98% of the samples, Geometric mean: 1.7µg/L (max value 34µg/L)
6-Oxo-Mono-propyl-heptyl phthalate (oxo-MiDP): detected in 89% of the samples, Geometric mean: 0.4µg/L (max value: 15.4µg/L)
Mono-(2,7-methyl-7-carboxy-heptyl) phthalate (cx-MiDP): detected in 95% of the samples, Geometric mean: 0.6µg/L (max value 16.3µg/L)
Applicant's summary and conclusion
- Executive summary:
Of the 21 Phthalate metabolites that were measured in the study, 18 could be detected in almoste all urine samples. Of these, the concentration of the metabolites of DIDP and DPHP (measured together) were by far the lowest in mothers and children. The results were comparable to those reported in other studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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