Registration Dossier
Registration Dossier
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EC number: 219-372-2 | CAS number: 2425-85-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-[(2,4-dinitrophenyl)azo]-2-naphthol
- EC Number:
- 222-429-4
- EC Name:
- 1-[(2,4-dinitrophenyl)azo]-2-naphthol
- Cas Number:
- 3468-63-1
- Molecular formula:
- C16H10N4O5
- IUPAC Name:
- 1-[(2,4-dinitrophenyl)diazenyl]-2-naphthol
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- arachis oil
- Remarks:
- BP
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal median lethal dose (LD50) of the test item in the Wistar strain rat was found to be greater than 2000 mg/kg bodyweight.
- Executive summary:
Mortality.There were no deaths.
Clinical Observations.Red/brown staining of the snout was noted in one male two hours after dosing. There were no other signs of systemic toxicity noted.
Dermal Irritation.Crust formation was noted at the test site of one female animal five and six days after dosing. No other signs of dermal irritation were noted.
Bodyweight. All animals showed expected gains in bodyweight over the study period.
Necropsy.No abnormalities were noted at necropsy
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