Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-836-8 | CAS number: 75-07-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to Guideline study with acceptable restrictions. In this test, the LC50 was determined and not the NOEC as required in OECD 204
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
- Deviations:
- yes
- Remarks:
- LC50 was determined instead of a NOEC
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetaldehyde
- EC Number:
- 200-836-8
- EC Name:
- Acetaldehyde
- Cas Number:
- 75-07-0
- Molecular formula:
- C2H4O
- IUPAC Name:
- acetaldehyde
- Details on test material:
- - Name of test material: Ethanal
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- - Chemical name of vehicle: acetone
- Concentration of vehicle in test medium: control fish were exposed to 72 µl acetone
Test organisms
- Test organisms (species):
- Poecilia reticulata
- Details on test organisms:
- TEST ORGANISM
- Common name: Poecilia reticulata
- Source: laboratory reared
- Age at study initiation: 2-3 month
ACCLIMATION
- Acclimation period: at least 12 days prior to experiment
- Acclimation conditions: same as test
- Type and amount of food: fish were fed a commercial food (TetraPhyll, Tetra Werke, Germany)
- Feeding frequency: daily
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 14 d
Test conditions
- Test temperature:
- 21 - 23°C
- pH:
- pH was determined four times immediately before, and immediately after renewal of the test solution for to concentrations. Results are not given in the study
- Dissolved oxygen:
- Oxygen content was determined four times immediately before, and immediately after renewal of the test solution for to concentrations. Results are not given in the study
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: closed
- Material, size, headspace, fill volume: 1.5 l glass vessels which contained 1.4 l of the test solution
- Renewal rate of test solution (frequency/flow rate): test solution was renewed daily
- No. of organisms per vessel: 10
OTHER TEST CONDITIONS
- Photoperiod: 12 hours light/12 hours dark
EFFECT PARAMETERS MEASURED: mortality
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 14 d
- Dose descriptor:
- other: log LC50
- Effect conc.:
- 2.9 µmol/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: log LC50 is given here which is originally stated in the report
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 794.3 µmol/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: converted value
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 35 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: converted value, based on a molar mass of 44.05 g/mol
- Reported statistics and error estimates:
- LC50 was calulates by logit transformation
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- After an exposure period of 14 day, the LC50 was determined to be 35 mg/l based on nominal values. Although a NOEC and not a LC50 is required according to the guideline, study is suitable as supporting information in the chemical safety assessment.
- Executive summary:
The prolonged toxicity of acetaldehyde was tested semi-static test over a period of 14 days similar to OECD 204. Guppies were used as test organisms. Fish were exposed to five test concentration using a spacing factor of 1.8. As endpoint, mortality was determined and LC50 was calculated by logit transformation. Analytical measurements could not be conducted because no reliable recovery factors could be determined and the results were therefore based on nominal values. The log LC50 which is stated in the report was calculated to be 2.9 µmol/l which corresponds to 35 mg/l based on nominal values.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.