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Diss Factsheets
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EC number: 209-544-5 | CAS number: 584-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Although the Fujiwara study indicates a NOAEC below 10 ppm, the results generated are of limited value only. The study was not performed to any standard protocol with experimental procedures carried out to a low standard.
Key value for chemical safety assessment
Additional information
Many details concerning the experimental set-up are lacking and there was no analytical monitoring performed. The latter is important as it can not be excluded that the water contained an unrealistic high concentration of TDA, depending on the mode of "stirring" of TDI into the water.
The chronic toxicity of the TDI hydrolysis product, TDA, was established in an OECD 212 study (III ref 11453) with an LOAEC of 10 mg/L (behaviour: odd swimming) and a NOAEC of 3.16 mg/l. The results of Yakabe et al, 1999 (see section 5.1.2 Hydrolysis) indicate that the hydrolysis of 10mg TDI/l may lead to the formation of about 4mg TDA/l. Therefore, the findings with TDI may be attributable to TDA. However, water is a carefully avoided reactant to TDI and is carefully controlled in all processes of TDI production and use. Vigorous stirring of TDI into water has no practical relevance. As a result of this and due to the poor quality of the chronic fish study, the value generated for the chronic fish toxicity of TDI should not be used for the Chemical Safety Assessment.
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