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EC number: 218-407-9 | CAS number: 2144-53-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The test substance is rapidly metabolised in vitro in mammalian and trout hepatocytes, as well as in vivo in rats. Predicted BCF for the test substance indicates that it would not bioaccumulate in fish.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
In an in vivo biopersistence and pharmacokinetic study, rats were given 300 mg/kg orally in a single dose. Blood plasma, liver, and fat were collected at various time points from 0 to 168 hours, and were analysed for presence of the test substance. The test substance was detected in very small amounts in plasma (< 40.0 ng/mL at the 1-, 2- and 4-hour post-dosing time points), liver (< 20.0 ng/mL at the 6-, 12-, and 24-hour post-dosing time points), and fat (< 20.0 to 99.9 ng/g at the 6-, 12-, 24-, 48-, 72-, and 96-hour post-dosing time points).
Metabolism of the test substance was examined in male and female rat hepatocytes and male mouse hepatocytes compared to heat inactivated controls. The half-life in male and female rat hepatocytes was reported as <3 minutes, as an actual rate was not attainable due to the fact that there was <5% of the parent compound remaining 5 minutes after incubation and no parent compound remaining after 15 minutes of incubation. Significant metabolism was also observed in male mice hepatocytes, but half- life and clearance rates could not be calculated due to the shape of the data curve. The steep portion of the curve between 0 and 3 minutes indicated rapid metabolism (5 µM to 1.1 µM). In the in vitro rat and mouse hepatocyte study, the largest metabolite was 6:2 uFTOH-GH. Additional major metabolites in rat hepatocytes included 6:2 GTOH-Gluc, 6:2 diOH-diGluc, 6:2 FTOH (by GC/MS), 6:2 FMA-GS (male hepatocytes only), 6:2 FTOH-Sulf (female hepatocytes only), and 6:2 UAL-GS (isomer II DNPH deriv.) (female hepatocytes only). Additional major metabolites in mouse hepatocytes included 6:2 UA-GS, 6:2 uFTOH-N-acetyl-GS, 5:2 OH-Gluc, 6:2 FTOH-Gluc, and 5-2 Ketone (DNPH deriv.).
Metabolism of the test substance was also examined in freshly isolated trout hepatocytes. Time-dependent disappearance of the test substance was observed. The steep portion of the curve between 0 and 30 minutes indicates rapid metabolism, with 83% loss of the parent compound. The curve shape in the live incubations was biphasic, with a rapid elimination phase in the first 30 minutes (alpha phase) and a slower rate between 30 and 90 minutes (beta phase). The calculated trout hepatic clearance for the test substance was 112.7 mL/h/kg. Based on the findings of this study, the predicted BCF for the test substance is 268, indicating that it would not bioaccumulate in fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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