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EC number: 203-457-6 | CAS number: 107-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1990-10-22 to 1990-11-13
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: - scientifically sound study - limited reporting, non-GLP - no substance purity information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- only two animals tested
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-chloropropene
- EC Number:
- 203-457-6
- EC Name:
- 3-chloropropene
- Cas Number:
- 107-05-1
- Molecular formula:
- C3H5Cl
- IUPAC Name:
- 3-chloroprop-1-ene
- Details on test material:
- - Name of test material (as cited in study report): Allylchlorid, BAS 480 F
- Physical state: not reported
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
- Composition of test material, percentage of components: not reported
- Purity test date: not reported
- Lot/batch No.: 23469-77BD
- Expiration date of the lot/batch:
- Stability under test conditions: not reported, but expected to be stable
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: no data, presumably shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Concentration (if solution): 100 %
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: not reported
- Type of wrap if used: semi occlusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with Lutrol and Lutrol 50 % (Lutrol = PEG 400)
- Time after start of exposure: 4 h
SCORING SYSTEM: Draize score system
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: average of scores at 24, 48 and 72 h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: see table 1 for individual animal information
- Irritant / corrosive response data:
- a mild redening was seen in both animals after 1 and 24 h which was fully reversible within 48 h in both.
- Other effects:
- no
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- 3-Chloropropene was tested for its potency to cause skin irritation in an in vivo test in rabbits according to OECD 404 using 0.5 g of substance. The only effect noted was a slight reddening of the treated skin that persisted for 24 h and was fully reversible within 48 h. No edema were reported. Based on this results the test item is not irritating in this test system and a classification according to CLP is not necessary
- Executive summary:
In the present study (BASF 1990) 3-Chloropropene was tested for its potency to cause skin irritation in an in vivo test in rabbits according to OECD 404 using 0.5 g of substance. The only effect noted was a slight reddening of the treated skin that persisted for 24 h and was fully reversible within 48 h. No edema were reported. Based on this results the test item is not irritating in this test system and a classification for skin irritation according to CLP as implementation of UN GHS in the EU (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL) is not necessary.
Animals were treated with 0.5 g of the undiluted test item on shaved skin followed by a incubation for 4 h under semiocclusive conditions. Subsequentially the solution was washed of with once 100 % Lutrol (= PEG 400) and once 50 % Lutrol in water. The formation of erythema and edema was scored at 60 min, 24, 48 and 72 h after the start of the incubation. As the initially developed slight reddening in both animals (erythema score 1, edema score 0) was fully reversible within 48 h the test was stopped 72 h after the start of treatment. Only two animals were treated, but as the effect is minimal and the results unequivocal, the test is judged to be reliable except for the uncertainty on substance purity.
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