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Diss Factsheets
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EC number: 203-686-1 | CAS number: 109-60-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficent detail (reliability adopted from OECD SIDS)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- In an effort to understand the respiratory bioavailability of aliphatic alcohols and esters, rats were placed into a whole-body plethysmograph. The wholebody plethysmograph is designed to measure (non-invasively) ventilatory movements on conscious rats. By collecting data on ventilatory movements, and chamber and venous blood propyl acetate concentrations, respiratory bioavailability determinations can be calculated.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propyl acetate
- EC Number:
- 203-686-1
- EC Name:
- Propyl acetate
- Cas Number:
- 109-60-4
- Molecular formula:
- C5H10O2
- IUPAC Name:
- propyl acetate
- Details on test material:
- n-propyl acetate, spectroscopic grade (>99.9%)
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hilltop Lab Animals, Inc.
- Age at study initiation: no data
- Weight at study initiation: 270-350 g
- Fasting period before study: no data
- Housing: no data
- Individual metabolism cages: no data
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +- 1 °C
- Humidity (%): 50 +- 20 %
- Air changes (per hr): 15-20/h
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- In an effort to understand the respiratory bioavailability of aliphatic alcohols and esters, a whole-body plethysmograph was installed in a gas-uptake
chamber. The rat has an indwelling jugular cannula implanted prior to study start and is placed in the plethysmograph. The plethysmograph
(containing the rat) is then placed in the gas-uptake chamber. The leads from the plethysmograph and the venous catheter are exteriorized from the
chamber for sample and data collection. The chamber is charged with 2000 ppm (= ca. 8.34 mg/L) propyl acetate and the chamber concentration decay curve is followed by gas chromatography. In addition, venous blood samples are taken at 0, 5, 10, 15, 20, 25, 30, 40, 50, 60, and 90 minutes. The wholebody plethysmograph is designed to measure (non-invasively) ventilatory movements on conscious rats. By collecting data on ventilatory
movements, and chamber and venous blood propyl acetate concentrations, respiratory bioavailability determinations can be calculated. Blood
samples from six animals were analyzed for n-propyl acetate and n-propyl alcohol concentrations. - Duration and frequency of treatment / exposure:
- 90 min, once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2000 ppm = ca. 8.34 mg/L (the chamber is charged with 2000 ppm propyl acetate and the concentration drops as the rat inhales the test article. Loss to chamber equipment and external surface of the rat is corrected for).
- No. of animals per sex per dose / concentration:
- 6 males
- Control animals:
- no
- Details on study design:
- no data
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled (delete / add / specify): blood
- Time and frequency of sampling: 5, 10, 15, 20, 25, 30, 40, 50, 60, and 90 min after injection of test material into the chamber
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Degradation product (CAS No./EC No./EINECS Name): 71-23-8/ 200-746-9/ propan-1-ol
Any other information on results incl. tables
The blood concentrations of n-propyl acetate and n-propyl alcohol during the exposure period are reported below.
Blood level concentrations following inhalation of propyl acetate vapor
Sampling time (min) |
Propyl acetate* |
Propyl alcohol* |
0 |
0 |
0 |
5 |
17 |
88 |
10 |
29 |
102 |
15 |
36 |
110 |
20 |
31 |
101 |
25 |
32 |
94 |
30 |
33 |
85 |
40 |
25 |
80 |
50 |
20 |
70 |
60 |
14 |
49 |
90 |
6 |
46 |
*mean μM whole blood
The presence of propyl alcohol following propyl acetate inhalation exposure clearly demonstrates that propyl alcohol was the major
metabolite of propyl acetate metabolism. Blood levels of propyl alcohol (88 μM) exceeded those of propyl acetate (17 μM) at the first time point measured (5 minutes into the exposure). At the next time point (10 minutes into exposure), the levels of propyl alcohol in the blood were approximately 3-fold higher (102 μM) than the blood levels of propyl acetate (29 μM). Propyl acetate levels peaked at 15 minutes (36 μM) and remained fairly level over the next 15 minutes. Chamber concentrations decreased from time zero, both due to loss to chamber equipment surfaces as well as uptake by the rat (data not shown). Blood propyl alcohol levels were up to 2.5 to 8-fold higher than blood propyl acetate levels from 10 to 90 minutes after the start of the exposure.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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