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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 931-801-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
According to Regulation (EC) No 1907/2006, Annex VIII, column 2, testing for the effects on fertility by a sccreening test is not required as a test for prenatal developmental toxicity (Annex IX, 8.7.2) is proposed for the structurally related substance erucamide (CAS 112-84-5) by the Lead Registrant of that substance, which will be used for read-across.
According to Regulation (EC) No 1907/2006, a 2-generation study for reproductive toxicity is not indicated unless repeated dose toxicity studies demonstrate adverse effects on reproductive organs. A subchronic repeated dose toxicity study is proposed for the structurally related substance erucamide (CAS 112-84-5) by the Lead Registrant for that substance who is also a member of the Fatty Amides Consortium, which will be used for read-across; therefore the need for a 2-generation study is dependent on the outcome of the proposed test.
Short description of key information:
Data waiving - Toxicity to reproduction screening
Data waiving - Toxicity to reproduction 2-generation study
Effects on developmental toxicity
Description of key information
Data waiving - Prenatal Developmental Toxicity study (OECD 414) for structurally related substance (CAS 112-84-5, erucamide) is proposed by the respective Lead Registrant which will be used for read-across.
Additional information
There is no data available on developmental toxicity and teratogenicity for oleamide.
Therefore, a Prenatal Developmental Toxicity Study (OECD 414) for the structurally related substance erucamide (CAS 112-84-5), which has been proposed by the Lead Registrant for that substance who is also a member of the Fatty Amides Consortium, will be shared and used for read-across to satisfy the data requirements for developmental toxicity / teratogenicity of oleamide. The utilisation of such surrogate data from a structurally related substance for regulatory purposes is reasonable and justified, especially in the light of animal welfare and considering the physical chemical and toxicokinetic similarities of oleamide and erucamide. Therefore, no individual prenatal developmental toxicity study with oleamide is proposed.
Justification for classification or non-classification
According to the criteria of the DSD and the CLP regulation the substance cannot be classified for toxicity to reproduction at the moment due to a lack of data. The required studies have been proposed for the structurally related substance erucamide (CAS 112-84-5), which will be used for read-across.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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