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EC number: 231-135-5 | CAS number: 7440-25-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 4 October 2000 to 13 October 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tantalum
- EC Number:
- 231-135-5
- EC Name:
- Tantalum
- Cas Number:
- 7440-25-7
- Molecular formula:
- Ta
- IUPAC Name:
- tantalum
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Physical state: Grey powder
- Storage conditions: Room temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Age at study initiation: at least 12 weeks
- Weight at study initiation: 2.4 - 2.8 kg
- Housing: individually in stainless steel cages with perforated floors
- Diet: standard laboratory rabbit diet ad libitum (Special Diet Services STANRAB (P) SQC pellet)
- Water: ad libitum (potable water for human consumption)
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 ± 2 °C
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12 hours dark / 12 hours light (0600 - 1800)
IN-LIFE DATES: From 4 October 2000 to 13 October 2000
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg
TREATMENT PROCEDURE
- The weight of the test material which when gently compacted occupied a volume of 0.1 mL exceeded 100 mg on all occasions. However, 100 mg only was placed in the lower everted lid of one eye of each animal. The eyelids were gently held together for one second before releasing. The contralateral eye remained untreated and served as a control. - Duration of treatment / exposure:
- The treated eyes were not washed following test material installation.
- Observation period (in vivo):
- All animals were observed daily for signs of ill health or toxicity. Examinations of the eyes were made 1, 24, 48 and 72 hours after installation.
- Number of animals or in vitro replicates:
- 3
One animal was treated in advance of the other two, to ensure that if a severe response was produced, no further animals would be exposed. - Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): irrigation was not performed.
SCORING SYSTEM: The reactions were scored in accordance with the numerical system outline in field "Any other information on materials and methods incl. tables".
TOOL USED TO ASSESS SCORE: Observation of the eyes was aided by the use of a handheld light.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- score of three animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: No corneal damage was observed
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- score of three animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: No iridial inflammation was observed
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Remarks:
- score of three animals
- Time point:
- 24/48/72 h
- Score:
- 0.1
- Reversibility:
- fully reversible within: 2 days
- Remarks on result:
- other: Redness was seen in the eye of one male rabbit after 24 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- score of three animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: No chemosis was observed
- Irritant / corrosive response data:
- No corneal damage or iridial inflammation was observed. Transient, hyperaemia of the blood vessels of the conjunctivae was seen in all animals, resolving completely by either one or two days after instillation.
Any other information on results incl. tables
Table 1: Ocular Reactions
Means of scores at approx. 24, 48 and 72 hours after administration | ||||
Animal No. | Corneal opacity | Iridial lesions | Conjunctival | |
Redness | Chemosis | |||
1389 | 0 | 0 | 0 | 0 |
1456 | 0 | 0 | 0.3 | 0 |
1457 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the test according to OECD 405, the test material elicited only transient, very slight conjunctival irritation in any of the animals during the course of the study, meaning that the test material does not require classification as an eye irritant. The study is considered to be reliable, relevant and adequate for risk assessment and classification and labelling purposes.
- Executive summary:
The eye irritation potential of the test material was determined in accordance with the standardised guidelines OECD 405, EU Method B.5 and EPA OPPTS 870.2400. Approximately 0.1 mL of test material was applied into one eye each of three rabbits and the animals assessed for 3 days to determine the grade of ocular reaction.
No corneal damage or any iridial effects were seen. Conjunctival effects consisted of transient, very slight irritation in one animal approximately 24 hours after installation. All signs of irritation had completely resolved 1 to 2 days following test material installation.
Under the conditions of the study, the test material is considered to be practically non-irritating to the eyes based on an internal system for description of irritation responses. The test material does not require classification for eye irritation in line with Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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