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EC number: 221-201-1 | CAS number: 3030-47-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion: study equivalent or similar to OECD Guideline 404, Vienna White rabbit m/f, 2 animals, occlusive coverage, observation 8 days, Result: Category 1B (corrosive).
Eye irritation: study equivalent or similar to OECD Guideline 405, Vienna White rabbit m/f, 2 animals, single application w/o rinsing, observation 8 days, Result: Category 1 (irreversible effects on the eye).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (limited documentation, occlusive treatment, no data on substance purity)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (limited documentation, 1, 5, 15 min and 20 h exposure duration, occlusive treatment, no scoring at 72 h)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- - Source: Gaukler
- Weight at study initiation: 2.94 kg (male), 3.78 kg (female) - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated site served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: area of application: 2.5 x 2.5 cm
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 1, 5, 15 min and 20 h
- Observation period:
- 8 days (reading intervals: upon removal of test patch, 24 h, 48 h, 5 d, 7 d, and 8 d after start of treatment)
- Number of animals:
- 2 (20 h exposure only in 1 animal)
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Remarks:
- (5 min exposure)
- Time point:
- other: 24 h
- Remarks on result:
- other: non-reversible, leather-like, black necrosis
- Irritation parameter:
- other: necrosis
- Basis:
- animal #2
- Remarks:
- (5 min exposure)
- Time point:
- other: 24 h
- Remarks on result:
- other: non-reversible leather-like, red-brown necrosis
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information
Reference
Skin irritation:
Exposure duration |
Readingpoint |
Animal 1 |
Animal 2 |
||||
Ery |
Ed |
Remarks |
Ery |
Ed |
Remarks |
||
1 min |
Day 0 |
2 |
0 |
Blotchy necrosis |
2 |
- |
blotchy |
24 h |
2 |
2 |
Necrosis, ecchymosis |
- |
- |
Blotchy necrosis |
|
48 h |
- |
- |
Blotchy necrosis |
- |
- |
Blotchy necrosis |
|
Day 5 |
- |
- |
Parchmenty necrosis |
- |
- |
Parchmenty necrosis |
|
Day 7 |
- |
- |
Scaling |
- |
- |
Scaling |
|
Day 8 |
- |
- |
Necrosis |
- |
- |
Scaling |
|
5 min |
Day 0 |
3 |
- |
Ecchymosis |
2 |
- |
Brownish |
24 h |
2 |
- |
Leather-like, black necrosis |
- |
- |
Leather-like, red-brown necrosis |
|
48 h |
- |
- |
Leather-like, hard necrosis |
- |
- |
Leather-like, red-brown necrosis |
|
Day 5 |
- |
- |
Hard, movable necrosis |
- |
- |
Leather-like, red-brown necrosis |
|
Day 7 |
- |
- |
Hard, movable necrosis |
- |
- |
Leather-like/hard red-brown necrosis |
|
Day 8 |
- |
- |
Hard, movable necrosis |
- |
- |
Leather-like/hard, red-brown necrosis |
|
15 min |
Day 0 |
3 |
- |
Ecchymosis, yellow |
2 |
- |
Brownish, overleaping necrotic centre |
24 h |
2 |
- |
Leather-like, black necrosis |
- |
- |
Hard, movable black necrosis |
|
48 h |
- |
- |
Leather-like, black necrosis |
- |
- |
Hard, movable black necrosis |
|
Day 5 |
- |
- |
Leather-like necrosis |
- |
- |
Hard, movable, black necrosis |
|
Day 7 |
- |
- |
Leather-like necrosis |
- |
- |
Hard, movable black necrosis |
|
Day 8 |
- |
- |
Leather-like necrosis |
- |
- |
Hard, movable black necrosis |
|
20 h |
24 h |
2 |
- |
Soft, black, anaemic necrosis |
|
|
|
48 h |
2 |
- |
Hard movable, black necrosis |
|
|
|
|
Day 5 |
- |
- |
Hard, movable necrosis |
|
|
|
|
Day 7 |
- |
- |
Hard, movable necrosis |
|
|
|
|
Day 8 |
- |
- |
Hard, movable necrosis |
|
|
Ery: Erythema
Ed: Edema
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (limited documentation, no data on substance purity)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (limited documentation, application amount)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- - Source: Gaukler
- Weight at study initiation: 3.37 kg (female), 3.32 kg (male) - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: adjacent eye served as control
- Amount / concentration applied:
- 50 mm³ of the undiluted test substance
- Duration of treatment / exposure:
- single application without rinsing
- Observation period (in vivo):
- 8 days (reading after end of treatment at 10 min, 1h, 3 h, 24 h, 48 h, 72 h, 4 d, 7 d and 8 d)
- Number of animals or in vitro replicates:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- (2 animals)
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24 h - 48 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 2.66
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information
Reference
Reading |
Animal 1 |
Animal 2 |
||||||||
Cornea |
Iris |
Conj |
Chem |
Remarks |
Cornea |
Iris |
Conj |
Chem |
Remarks |
|
10 min |
2 |
|
|
|
NMr, NP, S |
1 |
|
|
|
NMw, NP, S |
1 h |
2 |
|
|
1 |
NMr, BS |
2 |
|
|
1 |
NMw, BS |
3 h |
2 |
|
|
2 |
NMg, BS |
3 |
|
|
2 |
NMr, BS |
24 h |
3 |
|
2 |
2 |
NMg, CE |
3 |
|
2 |
4 |
Su, CE |
48 h |
3 |
|
|
2 |
NMg, S, N |
3 |
|
2 |
2 |
NMw, Su, CE |
72 h |
3 |
|
|
4 |
NMg, Su, CE |
3 |
|
|
4 |
NMg, Su, CE |
4 d |
3 |
|
|
4 |
N |
3 |
|
|
2 |
NMr, CE, Su |
7 d |
3 |
|
|
2 |
NMg, Su, CE |
3 |
|
|
2 |
NMr, Su, CE |
8 d |
3 |
|
|
2 |
N |
3 |
|
|
2 |
NMr, Su, CE |
Conj.: Conjunctivae Score
Chem: Chemosis Score
NMr: nictitating membrane red-brown; NMg: nictitating membrane grey; NMw: nictitating membrane white; NP: narrowed pupil; S: secretion; BS: bloody secretion
CE: crusted eyelids; N: necrotic eyelids; Su: suppuration
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Both key studies were reliable with restrictions, since there were deviations from the official OECD guidelines.
In skin irritation/corrosion testing, leather-like black necrosis was observed after 5 minute exposure in both animals. Results on corrosivity of the test substance were supported by 3 other studies, including 2 in vivo and 1 in vitro study.
Eye irritation testing showed not-fully reversible, or non-reversible changes of the cornea and conjunctiva.
Justification for selection of skin irritation / corrosion endpoint:
The study with the suitable duration of exposure and selection of the examination times was selected (equivalent or similar to OECD Guideline 404)
Justification for selection of eye irritation endpoint:
one study available, equivalent or similar to OECD Guideline 405
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on the results from skin irritation/corrosion and eye irritation testing, the substance is classified as corrosive - Skin Corr. 1B, H314 (Causes severe skin burns and eye damage) and Eye Dam. 1, H318 (Causes serious eye damage) according to the CLP Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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