Registration Dossier
Registration Dossier
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EC number: 214-302-7 | CAS number: 1120-24-7
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to OECD Guideline 105, adapted for n-octanol (hydrochloride)
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 105 adapted for n-octanol
- Medium:
- n-octanol
- Solubility:
- 159 000 mg/L
- Temp.:
- 20 °C
- Details on results:
- See below
- Conclusions:
- The solubility of the test substance (hydrochloride) in n-octanol is 159000 mg/L at 20 °C.
- Executive summary:
The solubility of the test substance (hydrochloride) in n-octanol was determined according to the OECD Guideline for the Testing of Chemicals 105, adapted for n-octanol. The solubility of the test substance in n-octanol is 159000 mg/L at 20 °C.
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to OECD Guideline 105, adapted for n-octanol (prelininary test only)
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 105 adapted for n-octanol
- Key result
- Medium:
- n-octanol
- Solubility:
- > 1 000 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Approximate value from preliminary test, but the overall result is that is miscible with n-octanol at every ratio.
- Details on results:
- See below
- Conclusions:
- The test substance is miscible with n-octanol at every ratio.
- Executive summary:
The solubility of the test substance in n-octanol was detelmined according to the OECD Guideline for the Testing of Chemicals 105, adapted for n-octanol. The test substance is miscible with n-octanol at 20 °C at every ratio.
Referenceopen allclose all
Preliminary test:
mL of n- octanol for 0.1 g soluble |
0.1 |
0.5 |
1 |
2 |
10 |
100 |
150 |
Approx. solubility in g/L |
>1000 |
1000 to 200 |
200 to 100 |
100 to50 |
50 to 10 |
10 to 1 |
<1 |
Visual evaluation |
not soluble |
not soluble |
soluble |
soluble |
soluble |
soluble |
soluble |
Solubility test:
| Flask No. | Equilibration time at 20 °C [h] | Solubility [mg/L] |
| 1 | 24 | 158000 |
| 2 | 48 | 159000 |
| 3 | 72 | 160000 |
| mean | --- | 159000 |
Individual titration results:
Day |
Weight of n-octanol phase [g] |
Volume of volumetric solution [mL] |
Test substance |
1 |
0.5122 |
8.40 |
158000 |
2 |
0.5174 |
8.55 |
159000 |
3 |
0.5050 |
8.40 |
160000 |
mean |
--- |
--- |
159000 |
Preliminary test:
mL of n- octanol for 0.1 g soluble |
0.1 |
0.5 |
1 |
2 |
10 |
100 |
150 |
Approx. solubility in g/L |
>1000 |
1000 to 200 |
200 to 100 |
100 to 50 |
50 to 10 |
10 to 1 |
<1 |
Visual evaluation |
soluble |
soluble |
soluble |
soluble |
soluble |
soluble |
soluble |
Description of key information
The test substance C10-DMA is miscible with n-octanol at every ratio.
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 778.3 g/L
Additional information
Solubility in n-octanol
Solubility in n-octanol was determined for C10-DMA and further members of the DMA category at ambient temperature (20-21 °C). C10-DMA was completely miscible with n-octanol, as was the case for the other DMAs tested. Accordingly, as the limit value, the respective density of the DMA was given as the solubility in n-octanol.
As supporting information, n-octanol solubility of the protonated form of C10-DMA (C10-DMA hydrochloride) as well as for other DMA hydrochlorides was determined. As could be expected, n-octanol solubility of the respective hydrochlorides is pronouncedly lower than neutral amine solubility. Full details are provided in the respective endpoint study records.
Solubility of DMAs and DMA hydrochlorides in n-octanol
| C10-DMA | C12-DMA | C14-DMA | C16-DMA | C18-DMA |
Octanol solubility* (g/L) – Amine | 778.3 | 784.6 | 793.0 | 800.9 | 806.0 |
Octanol solubility (g/L) – Hydrochloride | 159 | 114 | 89 | 60 | 22 |
* Completely miscible in n-octanol; value based on density of the substance
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