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Diss Factsheets
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EC number: 231-982-0 | CAS number: 7783-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
One reliable animal study, according to OECD guideline429 (Skin Sensitisation: Local Lymph Node Assay, modified according to Ehlings et al. 2005)and according to GLP has been performed for ammonium thiosulfate which shows that the test item has no sensitising properties.
The positive control group caused the expected increases in lymph node cell count (S.I.: 1.986) and lymph node weight (statistically significant at p ≤ 0.01). Therefore, the study is regarded as valid. The stimulation index for lymph node weight was 1.844 and for ear weight 1.198.
Migrated from Short description of key information:
Ammonium thiosulphate did not reveal any sensitising properties in the local lymph node assay (modified OECD 429, method according to Ehlings et al. 2005). Thus, ammonium thiosulphate does not require classification as sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
There is no evidence on specific respiratory hypersensitivity in test animals following acute inhalation exposure with ammonium thiosulphate.
Justification for classification or non-classification
Skin Sensitisation:
The reference Haferkorn (2010) is considered as the key study on skin sensitisation and will be used for classification. The overall sensitisation results are as follows:
Local lymph node assay (LLNA) in mice
SIs of less than 1.4 (0.546 - 0.940) were observed for lymph node cell count at all test concentrations of ammonium thiosulphate (10, 25, 50 %) and no dose response could be observed..
In addition, SIs of less than 1.1 (0.977 - 1.038) were observed for ear weight at all concentrations of ammonium thiosulphate (10, 25, 50 %).
Thus, the classification criteria acc. to Directive 67/548/EEC and Regulation (EC) 1272/2008 as skin sensitizer are not met.
Respiratory sensitisation
There is no evidence on specific respiratory hypersensitivity in humans following repeated inhalation exposure to ammonium thiosulphate. Furthermore, none of the repeated dose toxicity studies via inhalation reports respiratory hypersensitivity in the test animals. Thus, the classification criteria acc. to Directive 67/548/EEC and Regulation (EC) 1272/2008 as respiratory sensitiser are not met.
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