Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 250-418-4 | CAS number: 30989-05-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1974
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Increase in substance weight instead of decrease during IRT, probably due to hygroscopic properties of test substance. Therefore, one cannot be sure whether the animals were exposed to the test substance at all.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- GLP compliance:
- no
- Test type:
- other: Inhalation Risk Test (IRT)
- Limit test:
- no
Test material
- Reference substance name:
- Tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate
- EC Number:
- 250-418-4
- EC Name:
- Tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate
- Cas Number:
- 30989-05-0
- Molecular formula:
- C21H45BO12
- IUPAC Name:
- tris{2-[2-(2-methoxyethoxy)ethoxy]ethyl} borate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Substance type: Borated Glycol Ether
- Physical state: Clear colourless liquid
- Lot/batch No.: 4200 (SNC Sample No.); Indent 9450/9486
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: Not provided
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Gassner-Ratten (Gassner-rat)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Rate of air: 200 liter air/hour
"Inhalation einer mit Dampf bei C gesättigten Atmosphäre: 20 °C. Zur Sättigung wurde durch eine ca. 5 cm hohe Schicht des Produktes Luft geleitet"
(Inhalation of a vapour saturated atmosphere at 20 °C. In order to obtain saturation of the atmosphere, air was passed through a 5 cm column of the product.) - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- No. of animals per sex per dose:
- 3
- Control animals:
- yes
- Remarks:
- Exposure to pure air.
- Details on study design:
- - Exposure time: 8 h
- Duration of observation period following administration: 7 days
Further details were not provided.
Results and discussion
- Mortality:
- No mortality within 8 h exposure period and 7 day observation period.
- Clinical signs:
- other: No effects on clinical signs.
- Body weight:
- No effects on body weight.
- Gross pathology:
- No effects on gross pathology.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- No mortalities within 8 h exposure period.
- Executive summary:
A nominal concentration could not be calculated because the substance gained weight instead of lost weight during the test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)