Propan-1-ol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions (occlusive exposure) study prior to GLP; peer reviewed study (EU RAR)

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range finding toxicity data - List V -

Author:

Smyth H.F., Carpenter C.P., Weil C.S., Pozzani U.C

Year:

1954

Bibliographic source:

Arch. ind. hyg. occupat. med. 10, 61-68.

Reference 2

Reference Type:

secondary source

Title:

EU Risk Assessment Report, CAS No. 71-23-8: Propan-1-ol, Vol. 82

Author:

not applicable

Year:

2008

Bibliographic source:

ECB

Reference 3

Reference Type:

study report

Title:

Unnamed

Year:

1953

Report date:

1953

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

(occlusive treatment, only 4 males/dose)

Principles of method if other than guideline:

Draize, J.H. et al., J. Pharmacol. Exp. Therap., 82, 377, (1944)

The fur is closely clipped over the entire trunk, and the dose, retained beneath an impervious plastic film, contacts about 1/10 of the body surface. Dosages greater than 20 ml/kg cannot be retained in contact with the skin. After 24 hours contact the film is removed, and mortality is considered complete after 14 additional days.

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Propan-1-ol

EC Number:

200-746-9

EC Name:

Propan-1-ol

Cas Number:

71-23-8

Molecular formula:

C3H8O

IUPAC Name:

propan-1-ol

Specific details on test material used for the study:

Analytical purity: no data

Test animals

Species:

rabbit

Strain:

other: New Zealand giant albino rabbits

Sex:

male

Details on test animals or test system and environmental conditions:

- Weight at study initiation: 2.5-3.5 kg

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: 1/10 of body surface
- % coverage: no data
- Type of wrap if used: no data

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data

TEST MATERIAL
- Amount(s) applied: maximal 20 ml/kg bw
- Concentration (if solution): undiluted

Duration of exposure:

24 h

Doses:

no data

No. of animals per sex per dose:

4 male animals

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

4 032 mg/kg bw

95% CL:

2 720 - 5 968

Remarks on result:

other: Conversion with density: 0.8 g/ml (original data given in publication: 5.04 ml/kg bw with 95 % confidence limits of 3.4-7.46)

Mortality:

no data

Clinical signs:

other: no data

Gross pathology:

no data