Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
1 mg/kg bw/day
Study duration:

Additional information

Oral - The only effect that could be attributed to TNG in this study was a mild methemoglobinemia that was not accompanied by any of the sequelae of a severe methemoglobinemia such as Heinz bodies, elevated reticulocytes, and anemia. Except for the dogs receiving 25 mg TNG / kg / day, methemoglobin levels returned to zero after a thirty day recovery period.

Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: aorta

Justification for classification or non-classification

In accordance to the description in column 2 point 8.5.2 appendix VIII and results of measurements a conditions of work (see Exposure scenario for production of GTN and production of explosives) there doesn't exist vapors of GTN.