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EC number: 216-971-0 | CAS number: 1709-70-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Significant accumulation is not to be expected.
Key value for chemical safety assessment
Additional information
There are no robust studies available for the present substance. A weight-of-evidence approach was conducted to assess the bioaccumulation potential. Three different QSAR calculations with different models have been performed.
(1) Catalogic: BCF = 7.43
(2) T.E.S.T.: BCF = 501.39
(3) EPISuite BCFBAF: BCF = 3.16
The logKow was estimated to be 17.17.
According to column 2 of REACh Annex IX the study on bioaccumulation does not need to be conducted if the substance has a low potential for bioaccumulation (for instance a log Kow < 3) and/or a low potentail to cross biological mlembranes; or direct and indirect exposure of the aquatic compartment is unlikely.
The substance has a water solubility of < 8 microg/L which clearly limits the bioavailability towards aquatic organisms. Furthermore, due to the high adsorption potential (log Koc > 5.6) it is expected that the substance will bind to sewage sludge and be removed from the water phase. In total, the concentrations in the environmental water phase are expected to be very low and not relevant for bioaccumulation.
Furthermore, the substance is not expected to have a significant potential to cross biological membranes. The average maximum diameter is 2 nm and the molecular weight is > 700. According to ECHA's Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.11: PBT Assessment, substances with an average molecular diameter of > 1.7 nm plus a molecular weight of > 700 are not expected to have a BCF > 5000. Furthermore, the aquatic BCF of a substance is probably lower than 2000 L/kg if the calculated log Kow is higher than 10. The present substance has a calculated log Kow of 17.17.
The calculated BCF values range from 3.16 to 501.39 which is supported by a published study from NITE reporting BCF values of 1.2 and 6.8 at concentrations of 200 and 20 microg/L, respectively. These values support the above-mentioned assessment that the substance is not expected to significantly accumualte in aquatic organisms.
In conclusion, due to the very low bioavailabiltiy, the hindered uptake via biological membranes, the very high log Kow and the different QSAR calculations as well as the reported study from NITE, the substance is not expected to significantly accumulate in organisms. It can be concluded that it is not bioaccumulative (B) and not very bioaccumulative (vB).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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