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Diss Factsheets
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EC number: 202-708-7 | CAS number: 98-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data from secondary literature with collections of data from experimental studies, no details on experimental procedures and test results; reliability of data is not assignable
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Recherche de la relations entre toxicite de molecules d'interet industriel et proprietes physico-chimiques: test d'irritation des voies aeriennes superieures applique a quatre familles chimiques (In French)
- Author:
- Muller J, Greff G
- Year:
- 1 984
- Bibliographic source:
- Fd Chem Toxicol 22: 661-664
- Reference Type:
- review article or handbook
- Title:
- Evaluation of the sensory irritation test for the assessment of occupational health risk
- Author:
- Bos PMJ, Zwart A, Reuzel PGJ, Bragt PC
- Year:
- 1 992
- Bibliographic source:
- Crit Rev Toxicol 21: 423-450
- Reference Type:
- publication
- Title:
- Physicochemical properties of nonreactive volatile organic chemicals to estimate RD50: alternatives to animal studies
- Author:
- Alarie Y, Nielsen GD, Andonian-Haftvan J, Abraham MH
- Year:
- 1 995
- Bibliographic source:
- Toxicol Appl Pharmacol 134: 92-99
- Reference Type:
- review article or handbook
- Title:
- Development of a database for sensory irritants and its use in establishing occupational limits
- Author:
- Schaper M
- Year:
- 1 993
- Bibliographic source:
- Am Ind Hyg Assoc J 54: 488-544
Materials and methods
- Principles of method if other than guideline:
- Alarie test
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- Acetophenone
- EC Number:
- 202-708-7
- EC Name:
- Acetophenone
- Cas Number:
- 98-86-2
- Molecular formula:
- C8H8O
- IUPAC Name:
- 1-phenylethanone
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Swiss OF1
Administration / exposure
- Route of administration:
- inhalation: vapour
- Duration of treatment / exposure:
- 5 to 15 min
- Frequency of treatment:
- single
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Basis:
Examinations
- Examinations:
- RD 50: concentration that induces a 50 % decrease in the respiratory rate
Results and discussion
- Details on results:
- RD 50 = 100 ppm = 0.5 mg/L
Applicant's summary and conclusion
- Conclusions:
- With a RD50 of 100 ppm a comparably low concentration of acetophenone was needed to induce sensory irritation in mice.
- Executive summary:
A sensory irritation test (Alarie test) based on trigeminal nerve stimulation in the nasal mucosa of mice measures decreased respiratory frequency which is described as RD50 -value (= 50% decrease in the respiratory rate). For acetophenone a RD50 -value of 0.5 mg/l (= 100 ppm) was reported for Swiss OF1 mice in several review-like publications with compilations of RD-50 values for many substances. A comparably low concentration of acetophenone was needed to induce sensory irritation in this assay. However, details on experimental conditions and test results are unsufficiently documented in these publications, so that a reliability is not assignable.
Other authors have published that there was no dose-relationship nor histopathological changes (D. Zissu. Journal of Applied Toxicology, 1995, Vol: 15(3):207-213): “These experiments showed that the lesion intensity observed in the nasal passages varied with exposure duration and type of airborne chemical, but did not depend on the concentration of the substance. Results did not allow us to establish a relationship between the histopathological changes and the type of chemical family”. Further supported by Bos et al. (J Occup Environ Med., 2002, Oct;44(10):968-76): “No relation was found between the sensory irritation potential (as measured by the Alarie test) and local tissue damage (histopathological changes) in the respiratory tract after single or repeated exposure. It was concluded that the Alarie test is inappropriate to evaluate respiratory tract irritation. In addition, the available data do not support a quantitative potency ranking for man based on the RD50 obtained with experimental animals.”
Pinching study (Pinching and Doving, 1974, Brain Res., 82: 195-204) indicated the same conclusion in its summary: no dose effect relationship and was also of reliability 4, even if ACP was used at 1 dose and we did not found the primary source of the study.
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