Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 308-760-8 | CAS number: 98246-87-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test performed under GLP according guidelines, all quality criteria were met, no CoA but sufficient info on test substance in report.
- Remarks:
- The test uses an emulsifier (1.5% of total organic carbon), that allows dispersion of the insoluble substance. The emulsified dispersion is the only form in which the substance is commerscially available and used. In this test 96% biodegradation was found at day 28.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): AKD Dispersion
- Analytical purity:
- Aggregate state: liquid
- Water solubility: miscible in any ratio (aques solution)
- Colour: white
- Impurities (identity and concentrations): Basoplast 88 conc: 10 TL; water: 89.85 TL; Tamol NN 2901 (emulsifier) 100% (calc.) 0.15 TL
- homogeneity: homogeneous
- Lot/batch No.: 052/03
- Date of production: 02 July 2003
- Expiry date: 06 october 2003
- Special conditions for storage: storage at room temperature
- Storage stability: stable - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- Activated sludge from laboratory wastewater plant treating municipal sewage. Concentration of activated sludge in the test assay: 30 mg/l (dry substance) was pre-aerated for about two days before the start of the test
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- The biologically produced carbon dioxide is trapped and measured at day 0,1,3,5,7,10,12,14,17,21,24,27 and 28
At the end of the test (day 28) the pH in the test vessels is lowered to remove all the dissolved carbon dioxide.
To determine the removal of dissolved organic carbon, the dissolved organic carbon content is determined at the end (day 28) of the test.
Test set-up:
two test bottles (with test substance and inoculum) (110 mg ThCO2/test vessel)
two blanc controls (with inoculum but without test substance) -
one inhibiton control (with test substance and reference substance and inoculum) (220 mg ThCO2/test vessel)
one abiotioc control (without test substance and without inoculum) -
one reference control (with reference substance and with inoculum) (109.8 mg ThCO2 / test vessel)
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 96
- Sampling time:
- 28 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 94
- Sampling time:
- 28 d
- Details on results:
- biodegradation reference substance on day 28 : CO2/ThCO2 = 105 % ; DOC = 92%
biodegradation test substance on day 28: CO2/ThCO2 = 96%; DOC = 94% ; 10 day window met = yes
biodegradation inhibition control : CO2/ThCO2 = 91% ; DOC = 99%
The substance also met the ten day window criterion for ready biodegradable substances.
validity criteria:
differences between replicates at day 28 < 20%,
degradation of reference substance at day 14 >60%,
degradation of inhibition control after day 14 > 25%,
DIC in the blank control by test begin at 20 mg/l TOC test concentration <1 mg/l
CO2 production in the blank control <70 mg/l
TEST IS VALID !! - Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Tamol NN2901 was used as an emulsifier to increase the watersolubility and herewith the bioavailability of AKD. The contribution of the emulsifier to the carbon dioxide evolved will be negligilbe relative to that from AKD. AKD dispersion is biodegraded 96% (CO2 to ThCO2) at day 28 in the CO2 evolution test (OECD 301B) and should therefore be classified as readily biodegradable. AKD dispersion is also meeting the 10 day window criteria. Test is performed under GLP according guidelines and all the quality criteria are met.
- Executive summary:
The test substance (AKD Dispersion) is readily biodegradable (according the OECD criteria).
Reference
Description of key information
Key study is OECD 301 B (ready biodegradability) study (BASF 2003).
Two peer reviewed articles are used as supporting evidence for ready biodegradability of AKD.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
2-Oxetanone, 3-C12-16-alkyl-4-C13-17-alkylidene (CAS No. 84989-41-3) is commonly referred to in the industry as alkyl ketene dimer (AKD). Alkyl ketene dimers are produced with linear alkyl chains, the alkyl chain lengths vary from C14-C18.
The ready biodegradability of AKD was tested in the CO2 evolution test (OECD 301B). Due to the poor water solubility of the substance, a dispersion containing linear alkyl chains (C16-C18) and a small amount of emulsifier (1,5% of total organic carbon) was tested. The emulsified dispersion is the only form in which AKD is commercially available and used. In this test 96% biodegradation was found at day 28. The substance also met the ten day window criterion for ready biodegradable substances.
The biodegradation of dialkyl ketones formed upon hydrolysis of AKD is probably initiated by monoxygenases (enzyme) catalyzing a Baeyer-Villiger reaction (Kamerbeek, 2003). The ester formed by this reaction is readily hydrolyzed into an alcohol and a fatty acid. The further degradation of these compounds proceeds by b-oxidation with subsequent formation of two-carbon unit shorter fatty acids and acetyl-CoA, with eventual liberation of carbon dioxide. The b-oxidation cycle also handles unsaturated fatty acids. Isomerization of the double bonds occurs to ensure the correct positioning of the double bonds in the substrate for the b-oxidation sequence (Ratledge, 1994). Based on this biodegradation mechanism, the potential of microorganisms to degrade AKD with respect to varying alkyl chain lengths is expected to be comparable.
Alkyl ketene dimers are classified as readily biodegradable based on the ready biodegradability test result of 2-Oxetanone, 3-C12-16-alkyl-4-C13-17-alkylidene and the biodegradation mechanism of ketones.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)