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Diss Factsheets
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EC number: 202-951-9 | CAS number: 101-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study comparable to guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
- Reference Type:
- secondary source
- Title:
- Summary with cover letter dated 10/18/88; NTIS/OTS 516609, Doc I.D. 89-890000009 (1988)
- Author:
- EPA-OTS
- Year:
- 1 988
- Bibliographic source:
- Monsanto Co. (1984) Acute toxicity/irritation studies with 4-aminodiphenylamine (4-ADPA). Study BD-84-077 Summary with cover letter dated 10/18/88; NTIS/OTS 516609, Doc I.D. 89-890000009 (1988)
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of 4-aminodiphenylamine
- Author:
- Randall, D.J. and Bannister R.M.
- Year:
- 1 990
- Bibliographic source:
- Acute Toxicity Data 1: 63 - 64
Materials and methods
- Principles of method if other than guideline:
- Method: other: comparable to OECD TG 402 (EPA guideline: Section 81-2, acute dermal toxicity study November 1982, TSCA: health effects test guideline EPA August 1982,: acute exposure, dermal toxicity)
- GLP compliance:
- yes
- Test type:
- other: acute dermal toxicity study
Test material
- Reference substance name:
- N-(4-aminophenyl)aniline
- EC Number:
- 202-951-9
- EC Name:
- N-(4-aminophenyl)aniline
- Cas Number:
- 101-54-2
- Molecular formula:
- C12H12N2
- IUPAC Name:
- N1-phenylbenzene-1,4-diamine
- Details on test material:
- IUCLID4 Test substance: other TS: purity 98.9 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- physiological saline
- Duration of exposure:
- approx. 24 h
- Doses:
- 5000
- No. of animals per sex per dose:
- 5 per dose and sex
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: sporadic occurrence of nasal and ocular discharge and single occurrence of red and/or swollen eyes
Any other information on results incl. tables
RS-Freetext:
Dose range finding study:
no mortality seen up to highest dose evaluated
MORTALITY main study:
- Number of deaths at the single dose: none
CLINICAL SIGNS:
only a few animals showed reduced food consumption nasal and ocular
discharge and single occurrences of red and/or swollen eyes, were observed
Body weight:
most animals exhibited little or no weight change at day 7, but all gained weight between day 7 and 14.
Pharmacologic and toxicologic signs: most animals were free of significant signs of systemic toxicity, although some occurences of nasal discharge were seen as were single occurences of red and or swollen eyes, food consumption decrease and ocular discharge. One animal exhibited a swollen left eye and a red nictitating membrane in the same eye during the day of dosing and or the day after dosing.
POSTMORTEM OBSERVATION:
Observations were similar to those seen in control animals in this laboratory or were considered to represent normal physiological variation.
Applicant's summary and conclusion
- Executive summary:
The acute dermal toxicity of the test substance 4-ADPA was evaluated with New Zealand White rabbits in a GLP and Guideline study. No mortality was observed in the dose range finding study up to 5000 mg/kg bw. Thus, in the main study five male and five female rabbits were treated with 5000 mg/kg bw test substance for 24 hours, followed by a 14 d observation period. All animals survived throughout the study. Therefore, the dermal LD50 of 4-ADPA in rabbits is greater than 5000 mg/kg bw. Most animals were free of significant signs of systemic toxicity, although some occurrence of nasal discharge were seen as were single occurrence of red and/or swollen eyes, food consumption decrease and ocular discharge. One animal exhibited a swollen left eye and a red nictitating membrane in the same eye during the day of dosing and or the day after dosing (Monsanto 1984).
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