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Environmental fate & pathways

Henry's Law constant

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Henry's law constant
Type of information:
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Principles of method if other than guideline:
The result was obtained using an appropriate QSAR method (see attached QMRF and QPRF for details).

The model is Bond Contribution Method within the publicly available HenryWin v 3.20 program (USEPA 2011). The Henry’s Law Constant (HLC) is calculated based on chemical structure, as the sum of the bond contribution values for each chemical bond in the molecule. The bond contribution values were determined based on least-square regression analysis of measured HLCs for organic compounds. The authors of the QMRF have carried out additional validation and found the method to be applicable to organosilicon compounds.

USEPA 2011. HenryWin v. 3.20, US EPA. Estimation Programs Interface Suite™ (EPI Suite) for Microsoft® Windows, v 4.10. United States Environmental Protection Agency, Washington, DC, USA (2011). Available at
0 dimensionless
25 °C
Atm. press.:
1 013 hPa
0 Pa m³/mol
25 °C
Atm. press.:
1 013 hPa
A Henry's Law Constant value of 1.7E-7 Pa-m3/mol at 25°C was obtained for the silanol hydrolysis product using a validated QSAR estimation method. The result is considered to be reliable.

Description of key information

Key value for chemical safety assessment

Henry's law constant (H) (in Pa m³/mol):
at the temperature of:
25 °C

Additional information

HLC for the silanol hydrolysis product