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Diss Factsheets
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EC number: 228-250-8 | CAS number: 6197-30-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-MAR-30 through 1992-APR-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Octocrilene
- EC Number:
- 228-250-8
- EC Name:
- Octocrilene
- Cas Number:
- 6197-30-4
- Molecular formula:
- C24H27NO2
- IUPAC Name:
- 2-ethylhexyl 2-cyano-3,3-diphenylacrylate
- Details on test material:
- - Name of test material (as cited in study report): HR 92/600 154
- Physical state: viscous liquid
- Analytical purity: 98.5%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Mol: Russian
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Moellegard Breeding Centre ApS, Ejby, Lille Skensved, DK
- Weight at study initiation: 2.5 - 2.8 kg
- Housing: singly
- Diet: free access to feed pellet "Altromin 2123"
- Water: free access to water, acidified with hydrochloric acid to pH 2.5
- Acclimation period: one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 3°C
- Humidity (%): 55 +/-15%
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: not required; untreated eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL - Duration of treatment / exposure:
- treated eyes were washed after 24 hours
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: treated eyes were washed after instillation of fluorescent dye and prior to eye examination
- Time after start of exposure: 24 hours
SCORING SYSTEM: according to table contained in OECD TG No. 405
TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- There was no eye reaction noted in any animal at any time.
Any other information on results incl. tables
Rabbit No. 1 |
|
1 h |
24 h F |
48 h |
72 h |
Area opacity |
|
0 |
0 |
0 |
0 |
Cornea |
|
0 |
0 |
0 |
0 |
Iris |
|
0 |
0 |
0 |
0 |
Conjunctiva |
Chemosis |
0 |
0 |
0 |
0 |
Redness |
0 |
0 |
0 |
0 |
|
Discharge |
0 |
0 |
0 |
0 |
Rabbit No. 2 |
|
1 h |
24 h F |
48 h |
72 h |
Area opacity |
|
0 |
0 |
0 |
0 |
Cornea |
|
0 |
0 |
0 |
0 |
Iris |
|
0 |
0 |
0 |
0 |
Conjunctiva |
Chemosis |
0 |
0 |
0 |
0 |
Redness |
0 |
0 |
0 |
0 |
|
Discharge |
0 |
0 |
0 |
0 |
Rabbit No. 3 |
|
1 h |
24 h F |
48 h |
72 h |
Area opacity |
|
0 |
0 |
0 |
0 |
Cornea |
|
0 |
0 |
0 |
0 |
Iris |
|
0 |
0 |
0 |
0 |
Conjunctiva |
Chemosis |
0 |
0 |
0 |
0 |
Redness |
0 |
0 |
0 |
0 |
|
Discharge |
0 |
0 |
0 |
0 |
Rabbit No. 4 |
|
1 h |
24 h F |
48 h |
72 h |
Area opacity |
|
0 |
0 |
0 |
0 |
Cornea |
|
0 |
0 |
0 |
0 |
Iris |
|
0 |
0 |
0 |
0 |
Conjunctiva |
Chemosis |
0 |
0 |
0 |
0 |
Redness |
0 |
0 |
0 |
0 |
|
Discharge |
0 |
0 |
0 |
0 |
F= reading after instillation of fluorescent dye
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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