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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

Microibial inhibition:  NOEC 20 mg/L

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
20 mg/L

Additional information

In accordance with REACH Regulation 1907/2008 Annex VIII Column 2, testing need not be undertaken if microbial toxicity is unlikely (if the substance is insoluble in water or if the substance is readily biodegradable). In a test of ready biodegradability the substance was found to be readily biodegradable. Waiving of the endpoint is thus justified.

A NOEC value has been asssigned based on the concentration used in the ready bidegradability test.

In a review of the aquatic toxicity of eighteen phthalate esters, Staples et.al. (Environmental Toxicology and Chemistry, Vol. 16(5): 875-89l, 1997) summarises published literature on phthalate esters, including diethyl phthalate. No details are available on methodology but the following results are cited:

 

Test species

Fresh/salt

water

Measured/nominal

concentration

Test

duration

Endpoint/

criteria

EC50/LC50

(95%CL)

(mg/L)

NOEC

(LOEC)

(mg/L)

Protozoa

T. pyriformis

F

N

24 hours

Growth inhibition

-

50 (100)

Protozoa

T. pyriformis

F

N

48 hours

Growth inhibition

132

50 (100)

Laboratory digester culture

F

M

5-193 hours

Anaerobic metabolic inhibition

-

100

Protozoa

Entosiphon sulcatum

F

N

72 hours

5% inhibition of reproduction

-

- (19)

Bacteria

P. phosphoreum

S

N

5-30 minutes

Light inhibition

111

-

Bacteria

Pseudomonas putida

F

N

16 hours

3% inhibition of reproduction

-

- (400)

Protozoa

Uronema parduczi

F

N

20 hours

5% inhibition of reproduction

-

- (48)

This supports the view that the substance is not significantly toxic to microorganisms and that the assigned NOEC is conservative.