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EC number: 265-044-7 | CAS number: 64741-44-2 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C11 through C20 and boiling in the range of 205°C to 345°C (401°F to 653°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985-06-11 to 1985-12-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it was conducted according to or similar to guideline study OECD TG 405.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- group II had eyes washed.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 64741-44-2
- Cas Number:
- 64741-44-2
- IUPAC Name:
- 64741-44-2
- Reference substance name:
- Straight-run middle distillate
- IUPAC Name:
- Straight-run middle distillate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): API 83-11
- Molecular formula (if other than submission substance): Straight run middle distillate
- Molecular weight (if other than submission substance): Clear, pale-yellow liquid
- CAS number: 64741-44-2
- Gravity API: 36.2
- Sulfur wt %:0.30
- Nitrogen ppm: 80
- Boiling range (ASTM D-86 equiv) 10%: 488 °F
- Initial Boiling Point 366 °F
- End Boiling Point 735 °F
- Viscosity at 40°C cSt: 4.16
- Aniline Point °F: 171
- Composition % by MS:
olefins 2.0
aromatics 21.0
saturates 77.0
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Dutchland, Inc., Denver, Pennsylvania
- Age at study initiation: Approximately 14 weeks
- Housing: Individual in screen-bottomed cages
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12 hrs dark/ 12 hrs light
- Temperature (°C): 21 to 25
- Humidity (%): 58% t o 64%: relative humidity
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 millilitre - Duration of treatment / exposure:
- Animals in Group I were dosed in with API 83-11. The eyes remained unflushed.
Animals in Group II: Eyes were flushed for one minute, 20 to 30 minutes aftre instillation. - Observation period (in vivo):
- Readings of occular lesions in the treated eyes of both groups were made at 1, 24, 48, and 72 hours and at 7 days after treatment.
- Number of animals or in vitro replicates:
- Six animals were dosed in Group I and 3 animals were dosed in Group II.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Animals in Group II had eyes flushed with warm water for 1 minute, 20 to 30 minutes after treatment. Group I eyes were not flushed.
- Time after start of exposure: 20 to 30 minutes after instillation.
SCORING SYSTEM: Draize Technique
TOOL USED TO ASSESS SCORE: Fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 80
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 10
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: Slight irritation noted at 24 hours; mean averages to 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: included within conjunctivae scoring
- Irritant / corrosive response data:
- No sign of systemic toxicity was observed during the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No pain response (vocalization) was elicited from any animal following instillation of the test material. No corneal irritation was seen during the study. All irritation had cleared by the 48-hour observation. No sign of systemic toxicity was observed during the study.
- Executive summary:
In a primary eye irritation study, 0.1 millilitre of a straight run middle distillate was instilled into the conjunctival sac of one eye of nine young adult New Zealand White rabbits. The eyes of three rabbits were washed, twenty to thirty minutes after instillation. The remaining six rabbits were not washed. Animals were observed 1, 24, 48, and 72 hours and at 7 days after treatment. The mean conjunctivae, iridial and corneal scores at 24, 48 and 72 hours post-exposure were 0. The test material was not found to be irritating to rabbit eyes. Irritation was scored by the method of Draize.
This study received a Klimisch score of 1 and is classified as reliable without restriction because it was conducted according to or similar to guideline study OECD TG 405.
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