Registration Dossier
Registration Dossier
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EC number: 200-820-0 | CAS number: 74-89-5
Endpoint summary
Administrative data
Description of key information
The data of irritation potential of methylamine are waived from the acute toxicity studies (see 7.2.1. Acute toxicity oral, BASF-Test and 7.2.2. Acute toxicity inhalation, BASF-Test, Acute toxicity dermal: Goffman and Maguire, 1980).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Monomethylamine caused eye, nose and throat irritation if inhaled. Administered orally to the rats, methylamine was corrosive to stomach. Liquefied methylamine (or in contact with moist skin) caused necrosis in the guinea pigs skin which was evident for histological evaluation after 48 hours. In concentrations of 141 ppm a 50 % decrease of the respiratory rate in rats was found (Gagnaire etal., 1989).
Effects on skin
irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Classification & Labeling:
Monomethylamine (aqueous solution) is classified according to GHS as: Skin Corr. 1B, H314: Causes severe skin burns and eye damage
Monomethylamine (gaseous form) is classified according to GHS as: Skin Irrit. 2 , Eye damage 1, H315: Causes skin irritation, H318: Causes serious eye damage
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