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Diss Factsheets
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EC number: 212-819-2 | CAS number: 872-05-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified reliable with restrictions, because although the study was well conducted, there is no statement regarding whether this study was conducted according to GLP or equivalent.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: other routes
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified reliable with restrictions, because although the study was well conducted, there is no statement regarding whether this study was conducted according to GLP or equivalent.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Though the study did not follow a prescribed guideline, it was well conducted and documented.
- GLP compliance:
- no
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not provided
- Age at study initiation: Not provided
- Weight at study initiation: 200 to 300 grams
- Fasting period before study: Not reported
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data - Route of administration:
- other: other: Material delivered into the mouth as a liquid or an aerosol
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Test material was administered into the animals mouth and was allowed to aspirate.
- Doses:
- Until all of the administered test material had been aspirated; specific duration is not reported.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- Groups of 5 anesthetized male albino Wistar rats were either administered 0.2 millilitre or 1 millilitre of liquid or aerosolised test material respectively into the mouth. When breathing resumed and was regular after test material administration, the animals’ nostrils were closed with fingers during the end of expiration phase to promote aspiration of the test material. This process was repeated until all of the test material had been aspirated. After dosing, animals were observed for a minimum of 4 hours at intervals ranging from 5 to 30 minutes. Animals that survived for 24 hours were sacrificed and lungs were weighed and received gross necropsy. Twenty undosed animals served as controls.
- Statistics:
- No data reported.
- Sex:
- male
- Dose descriptor:
- other: Aspiration hazard
- Effect level:
- other: Hex-1-ene is toxic when aspirated causing rapid death in 3 of the five treated animals. Two of the live animals reportedly did not aspirate any test material since hex-1-ene "boiled out of the mouth" before it was aspirated.
- Mortality:
- Three rats receiving 1 -hexene died within 24 hours.
- Clinical signs:
- Additionally, rats dosed with 1 -hexene exhibited central nervous system effects.
- Body weight:
- No data reported.
- Gross pathology:
- Lung weights of these animals did not differ significantly form control animals. Study authors reported that grossly, pathologically, lungs of these animals displayed typical “liver-like lungs.”
- Conclusions:
- The study authors concluded that 1-hexene is toxic when aspirated causing rapid death in 3 of the five treated animals. Two of the live animals reportedly did not aspirate any test material since 1-hexene "boiled out of the mouth" before it was aspirated.
- Executive summary:
In an acute toxicity study, eight homologous series of n-alkenes (n-olefins), including 1-hexene, were evaluated for their potential to cause acute toxicity using an aspiration process. Groups of 5 anesthetized male albino Wistar rats were either administered 0.2 millilitre or 1 millilitre of liquid or aerosolized test material respectively into the mouth. When breathing resumed and was regular after test material administration, the animals’ nostrils were closed with fingers during the end of expiration phase to promote aspiration of the test material. This process was repeated until all of the test material had been aspirated. After dosing, animals were observed for a minimum of 4 hours at intervals ranging from 5 to 30 minutes. Animals that survived for 24 hours were sacrificed and lungs were weighed and received gross necropsy.
Three rats receiving 1 -hexene died within 24 hours. Additionally, rats dosed with 1 -hexeneexhibited central nervous system effects.Lung weights of these animals did not differ significantly form control animals.Study authors reported that grossly, pathologically, lungs of these animals displayed typical "liver-like lungs."
A quantitative estimate of acute toxicity was not reported for this study.Based on the study outcome, the study authors concluded that 1-hexene is toxic when aspirated causing rapid death in 3 of the five treated animals. Two of the live animals reportedly did not aspirate any test material since 1-hexene "boiled out of the mouth" before it was aspirated.
This study received a Klimisch score of 2 and is classified as “reliable with restrictions”because although the study was well conducted, there is no statement regarding whether this study was conducted according to GLP or equivalent.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 963
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Though the study did not follow a prescribed guideline, it was well conducted and documented.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Hex-1-ene
- EC Number:
- 209-753-1
- EC Name:
- Hex-1-ene
- Cas Number:
- 592-41-6
- Molecular formula:
- C6H12
- IUPAC Name:
- hex-1-ene
- Details on test material:
- - Name of test material (as cited in study report): 1-Hexene
- Substance type: C6 alpha olefin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not provided
- Age at study initiation: Not provided
- Weight at study initiation: 200 to 300 grams
- Fasting period before study: Not reported
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
Administration / exposure
- Route of administration:
- other: other: Material delivered into the mouth as a liquid or an aerosol
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Test material was administered into the animals mouth and was allowed to aspirate.
- Doses:
- Until all of the administered test material had been aspirated; specific duration is not reported.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- Groups of 5 anesthetized male albino Wistar rats were either administered 0.2 millilitre or 1 millilitre of liquid or aerosolised test material respectively into the mouth. When breathing resumed and was regular after test material administration, the animals’ nostrils were closed with fingers during the end of expiration phase to promote aspiration of the test material. This process was repeated until all of the test material had been aspirated. After dosing, animals were observed for a minimum of 4 hours at intervals ranging from 5 to 30 minutes. Animals that survived for 24 hours were sacrificed and lungs were weighed and received gross necropsy. Twenty undosed animals served as controls.
- Statistics:
- No data reported.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: Aspiration hazard
- Effect level:
- other: Hex-1-ene is toxic when aspirated causing rapid death in 3 of the five treated animals. Two of the live animals reportedly did not aspirate any test material since hex-1-ene "boiled out of the mouth" before it was aspirated.
- Mortality:
- Three rats receiving 1 -hexene died within 24 hours.
- Clinical signs:
- Additionally, rats dosed with 1 -hexene exhibited central nervous system effects.
- Body weight:
- No data reported.
- Gross pathology:
- Lung weights of these animals did not differ significantly form control animals. Study authors reported that grossly, pathologically, lungs of these animals displayed typical “liver-like lungs.”
Applicant's summary and conclusion
- Conclusions:
- The study authors concluded that 1-hexene is toxic when aspirated causing rapid death in 3 of the five treated animals. Two of the live animals reportedly did not aspirate any test material since 1-hexene "boiled out of the mouth" before it was aspirated.
- Executive summary:
In an acute toxicity study, eight homologous series of n-alkenes (n-olefins), including 1-hexene, were evaluated for their potential to cause acute toxicity using an aspiration process. Groups of 5 anesthetized male albino Wistar rats were either administered 0.2 millilitre or 1 millilitre of liquid or aerosolized test material respectively into the mouth. When breathing resumed and was regular after test material administration, the animals’ nostrils were closed with fingers during the end of expiration phase to promote aspiration of the test material. This process was repeated until all of the test material had been aspirated. After dosing, animals were observed for a minimum of 4 hours at intervals ranging from 5 to 30 minutes. Animals that survived for 24 hours were sacrificed and lungs were weighed and received gross necropsy.
Three rats receiving 1 -hexene died within 24 hours. Additionally, rats dosed with 1 -hexeneexhibited central nervous system effects.Lung weights of these animals did not differ significantly form control animals.Study authors reported that grossly, pathologically, lungs of these animals displayed typical "liver-like lungs."
A quantitative estimate of acute toxicity was not reported for this study.Based on the study outcome, the study authors concluded that 1-hexene is toxic when aspirated causing rapid death in 3 of the five treated animals. Two of the live animals reportedly did not aspirate any test material since 1-hexene "boiled out of the mouth" before it was aspirated.
This study received a Klimisch score of 2 and is classified as “reliable with restrictions”because although the study was well conducted, there is no statement regarding whether this study was conducted according to GLP or equivalent.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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