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EC number: 265-077-7 | CAS number: 64741-76-0 A complex combination of hydrocarbons from the distillation of the products from a hydrocracking process. It consists predominantly of saturated hydrocarbons having carbon numbers in the range of C15-C39 and boiling in the range of approximately 260°C to 600°C (500°F to 1112°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Multiple studies were available to assess the skin sensitising potential of other lubricant base oils.
Sufficiently Refined Other Lubricant Base Oils (IP 346 < 3%)
In a key dermal sensitisation study (API, 1982a) 1.0 mL of test substance solvent dewaxed light paraffinic oil (CAS 64742-56-9, sufficiently refined, IP 346 < 3%) was applied to shaved skin of Hartley Albino guinea pigs under occlusive dressing once per week for three weeks with each exposure lasting 6 hours. The challenge dose (1.0 mL test material) occurred two weeks after the last induction dose. The challenge mean Draize scores were zero for erythema and oedema; therefore, solvent dewaxed light paraffinic oil was not considered to be a dermal sensitizer.
In a study conducted with human volunteers (Exxon Biomedical Sciences, Inc. (1988d)), 112 human adults were dermally exposed to 0.2 mL of severely hydrotreated heavy naphthenic distillate (IP 346 < 3%) once a day, 4 days a week, for 13 exposures. A challenge phase was conducted where the participants were treated with 0.2 mL once a day, 4 days a week, for one week. The test substance was considered not sensitising due to the small number of slight or mild irritation responses recorded.
Supporting data from studies conducted in guinea pigs (API, 1982b; 1982c; 1982d; 1982e; 1982f; 1982g; 1986b; UBTL, 1984w, 1984x, 1984y; 1984z; 1984aa; 1984ab; 1984ac; 1984ad; 1984ae; 1984af; 1984ag; 1984ah; and Trimmer et al. 1989) and human volunteers (Exxon Biomedical Sciences, Inc., 1988e; 1988f; 1988g) demonstrate that sufficiently refined other lubricant base oils (IP 346 < 3%) are not dermal sensitizers.
Insufficiently Refined Other Lubricant Base Oils (IP 346 = 3%)
In a key dermal sensitisation study (API, 1986a), a 50% mixture of test substance hydrotreated light naphthenic oil (CAS 64742-53-6, insufficiently refined, IP 346 = 3%) with paraffin oil was applied to Hartley Albino guinea pigs under occlusive dressing during an induction phase of three weekly applications, each with a 6-hour exposure. A challenge dose (1% test substance in paraffin oil) on a naïve site was given two weeks after the third induction application. Only one animal exhibited slight erythema during the challenge phase; therefore, the test substance was considered not sensitising.
Insufficiently refined other lubricant base oils (IP 346 = 3%) are not considered to be dermal sensitizers.
Migrated from Short description of key information:
Two key studies were identified for skin sensitisation, and the studies indicate that other lubricant base oils (sufficiently refined and insufficiently refined) do not cause allergic contact dermatitis.
Justification for selection of skin sensitisation endpoint:
One of Twenty Two skin sensitisation studies.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Migrated from Short description of key information:
This endpoint is not a REACH requirement.
Justification for classification or non-classification
Other lubricant base oils (sufficiently refined and insufficiently refined) do not meet the criteria for classification as dermal sensitizers under Annex VI of the EU CLP Regulation (EC No. 1272/2008).
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