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Diss Factsheets
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EC number: 202-327-6 | CAS number: 94-36-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- An updating report on cancer among benzoyl chloride manufacturing workers
- Author:
- Sakabe H and Fukuda K
- Year:
- 1 977
- Bibliographic source:
- Ind. Health, 15: 173-174
Materials and methods
- Study type:
- health record from industry
- Endpoint addressed:
- carcinogenicity
Test material
- Reference substance name:
- Dibenzoyl peroxide
- EC Number:
- 202-327-6
- EC Name:
- Dibenzoyl peroxide
- Cas Number:
- 94-36-0
- Molecular formula:
- C14H10O4
- IUPAC Name:
- diphenylperoxyanhydride
Constituent 1
Method
- Type of population:
- occupational
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Two cases of lung cancer were reported among workers in a small chemical plant producing benzoyl peroxide, benzoyl chloride, and related com pounds. Both workers were exposed to benzoyl peroxyde during its manufacture, and one of them was a smoker. Other compounds to which these workers were exposed included benzoyl chloride and benzotrichloride. Based on the development of lung cancer in others occupationally exposed to these latter two compounds, the au thors suggested that there is causal association between exposure to benzoyl chloride and benzotrichloride and lung cancer. However, the study did not indicate measurement of exposure levels to these or other compounds, nor did it control for the potential influence of smoking habits or exposure to other agents. The authors draw no specific conclusions regarding the risk of benzoyl peroxide exposure, and a review of these data provides no basis for a causal link between benzoyl peroxide exposure and cancer development in the two workers discussed by Sakabe and Fukuda (1977). Rather, as indicated above, the authors attributed the cancer cases to benzoyl chloride and/ or benzoyl trichloride exposure.
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