Registration Dossier
Registration Dossier
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EC number: 203-441-9 | CAS number: 106-91-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Ou-Yang
- Year:
- 1 988
- Bibliographic source:
- Ou-Yang, G.S. et al., J.Hyg.Res., 17 (3), 1-5 (1988)
- Title:
- No information
- Author:
- OECD
- Year:
- 1 999
- Bibliographic source:
- OECD SIDS for glycidyl methacrylate, December 1999
Materials and methods
Test guideline
- Guideline:
- other: no data
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,3-epoxypropyl methacrylate
- EC Number:
- 203-441-9
- EC Name:
- 2,3-epoxypropyl methacrylate
- Cas Number:
- 106-91-2
- Molecular formula:
- C7H10O3
- IUPAC Name:
- oxiran-2-ylmethyl methacrylate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: domestic
Test system
- Amount / concentration applied:
- 0.1 ml (100 mg)
- Duration of treatment / exposure:
- 5 days
- Observation period:
- 5 days
- Details on study design:
- One piece of undamaged skin two by two centimetres on either side of the spine was chosen for the testing, one side for testing and the other for control (an equal amount of tap water). 0.1 ml of original concentration of glycidyl methacrylate was applied for five days. The localized skin reaction was observed daily. After the experiments, the skin was removed for microscopic examination.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- other: 5 days
- Score:
- 4
- Max. score:
- 6
- Irritant / corrosive response data:
- After application for one or two days, the test areas turned red, swelled and blistered. After three days, there was subdermal bleeding and ulcers. After five days the skin turned hard, become thicker and cracked, and there was pigmentation. The tissue pathological changes included degeneration and necrosis of surface skin cells, disappearance of cellular boundaries, displaying pink staining material, bleeding in the corium cells and lymph cell infiltration with accompanying formation of abscesses.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
