Registration Dossier
Registration Dossier
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EC number: 203-366-1 | CAS number: 106-14-9
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Oct. 2010 to Nov. 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to standard guidelines and in compliance with GLP.
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 12-hydroxystearic acid
- EC Number:
- 203-366-1
- EC Name:
- 12-hydroxystearic acid
- Cas Number:
- 106-14-9
- Molecular formula:
- C18H36O3
- IUPAC Name:
- 12-hydroxyoctadecanoic acid
- Details on test material:
- - Name of test material (as cited in study report): 12-hydroxystearic acid (CAS N° 106-14-9, EC N° 203-366-1)
- Substance type: Fatty acid
- Physical state: Solid / white-yellowish
- Expiration date of the lot/batch: 09 April 2011
- Storage condition of test material: In original container, at room temperature (15 - 25°C), in the dark
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 5.7
Any other information on results incl. tables
The partition coefficient was calculated based on a calibration curve using 6 regerence items. The difference between the three measurements of the reference mixture was less than the given 0.1 log units. Therefore, the study was considered valid.
Applicant's summary and conclusion
- Conclusions:
- The logarithmic partition coefficient (n-octanol/water) of the test substance was determined to be 5.7 using the HPLC method.
- Executive summary:
A study was conducted to determine the n-octanol/water partition coefficient of 12 -hydroxystearic acid according to OECD Guideline 117 using the HPLC method.
The partition coefficient was calculated based on a calibration curve using 6 reference items.
The logarithmic partition coefficient (n-octanol/water) of the test substance was determined to be 5.7.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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