Registration Dossier
Registration Dossier
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EC number: 202-500-6 | CAS number: 96-33-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study acceptable for assessment (short summary report available)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Further experience with the range finding test in the industrial toxicology laboratory.
- Author:
- Smyth HF and Carpenter CP
- Year:
- 1 948
- Bibliographic source:
- J. Ind. Hyg. Tox. 30: 63-68
- Reference Type:
- secondary source
- Title:
- Further experience with the range finding test in the industrial toxicology laboratory
- Author:
- Smyth H.F. und Carpenter C.P.
- Year:
- 1 948
- Bibliographic source:
- J. Ind. Hyg. Tox., 30, 63-68; cited in MAK Begruendung Methylacrylat (1985) (in German)
Materials and methods
- Principles of method if other than guideline:
- Acute dermal toxicity study in rabbits conducted according to the method described by Draize et al. (1944).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl acrylate
- EC Number:
- 202-500-6
- EC Name:
- Methyl acrylate
- Cas Number:
- 96-33-3
- Molecular formula:
- C4H6O2
- IUPAC Name:
- methyl prop-2-enoate
- Details on test material:
- - Name of test material (as cited in study report): Methyl acrylate
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: MethyI "Cellosolve" solvent
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: rubber cuff application - Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 250 mg/kg bw
- Remarks on result:
- other: original data: LD50 = 1.3 mL/kg; calculated with a density of 0.96 g/mL
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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