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EC number: 274-685-1 | CAS number: 70592-78-8 A complex combination of hydrocarbons produced by the vacuum distillation of the residuum from atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C15 through C50 and boiling in the range of approximately 270°C to 600°C (518°F to 1112°F). This stream is likely to contain 5 wt.% or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Heavy Fuel Oil Components are no more than moderately irritating to skin under occlusive dressing post 24-hours exposure (insufficient for classification), and non-irritating to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation
The dermal irritation potential of Heavy Fuel Oil Components toward intact and abraded skin has been investigated in a large number of studies using open or occluded skin contact and exposure periods of 4 h or 24 h duration. In all instances dermal responses (erythema, oedema, dryness, cracking etc) were recorded using Draize criteria.
In a key dermal irritation study (API, 1980b), 0.5 mL of the test material was applied to the clipped skin of New Zealand White rabbits (3/sex) for 24 hours. The test material was applied to both abraded and non-abraded skin areas and covered with a closed patch (occlusive dressing). The animals were monitored over 72 hours post exposure and scored according to the Draize scale. Significant skin irritation was not observed following treatment.
Data from multiple supporting studies (ARCO, 1992o-s; 1990d,e; 1989d-f; 1987f; 1986d,e; Mobil, 1992c; 1988f-h; and API, 1980a,c,d) indicate a variable capacity to elicit skin irritation with no consistent difference in the relative intensity or relative persistence of skin reactions following 4 or 24 h contact, or exposure under occluded or open conditions. Hence although the conditions used in the majority of studies deviate from those of guideline recommendations, findings of erythema and oedema scores less than 2 in a majority of cases indicates that Heavy Fuel Oil Components are no more than moderately irritating to skin.
Eye Irritation
Information on the eye irritation potential of Heavy Fuel Oil Components is available from a large number of GLP-compliant studies that followed guideline recommendations. In all instances, neat test substance (0.1 mL) was instilled into the eye of 3-6 rabbits, the eyelids held shut for a few seconds before releasing, and ocular responses recorded using Draize criteria.
In a key eye irritation study (API, 1980b), six New Zealand White rabbits were treated with 0.1 mL of No 6 heavy fuel oil. An additional three animals were also treated with 0.1 mL of test substance, following which their eyes were rinsed with water. Effects on the eyes were monitored over 7 days with scoring according to the Draize scale. Corneal opacities of grade 1 and area 1 were seen in some animals at the 24 and 48-hour reading. No iridial inflammation was seen in any of the test animals. Conjunctival irritation was seen in all of the rabbits at 24 and 48 hours post dosing. All rabbits were negative for irritation after 7 days. The test substance was therefore considered to be mildly irritating.
Data from multiple supporting studies (ARCO, 1992t,u; 1991a-c; 1990f,g; 1989g-i; 1988a; 1986f,g; Mobil, 1992d; 1988i-k; and API 1982a; 1980a,c,d) indicate no more than mild or mild-moderate reversible irritation (mean intensity less than 2) of the rabbit eye, reflecting redness or swelling (chemosis) of the conjunctivae with mild corneal opacity or discharge occurring rarely. Overall, Heavy Fuel Oil Components appear to cause no more than transient, fully reversible eye irritation.
Justification for selection of skin irritation / corrosion endpoint:
One of 21 available studies.
Justification for selection of eye irritation endpoint:
One of 22 available studies.
Justification for classification or non-classification
The dermal irritation potential of samples of Heavy Fuel Oil Components has been tested in a large number of generally GLP-compliant rabbit skin irritation studies. The majority of data were derived using a 24 hr occluded exposure protocol. The conclusions of these studies indicate a potential to evoke no more than moderate skin irritation, with no evidence of injuries in depth (corrosion). The eye irritation potential of samples of Heavy Fuel Oil Components has been tested in a number of generally GLP-compliant near-guideline rabbit eye irritation studies. None of the samples tested elicited more than transient, fully reversible eye irritation. No classification is required under the EU CLP Regulation (EC No. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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