Propan-2-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1948

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study without detailed documentation.

Data source

Reference

Reference Type:

publication

Title:

FURTHER EXPERIENCE WITH THE RANGE FINDING TEST IN THE INDUSTRIAL TOXICOLOGY LABORATORY

Author:

Smyth HF & Carpenter CP

Year:

1948

Bibliographic source:

J Ind Hyg Toxicol 30(1):63-68

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

reliability scoring based on 2001 guideline for Test No. 423

Deviations:

yes

Remarks:

Lacking detail in methodology and results

GLP compliance:

no

Remarks:

Study pre-dates GLP requirements

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propan-2-ol

EC Number:

200-661-7

EC Name:

Propan-2-ol

Cas Number:

67-63-0

Molecular formula:

C3H8O

IUPAC Name:

propan-2-ol

Details on test material:

- Name of test material (as cited in study report): Isopropanol

Test animals

Species:

rat

Strain:

Sherman

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: Not reported
- Fasting period before study: Not reported
- Housing:Not reported
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum):Not reported
- Acclimation period:Not reported


ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light):Not reported


IN-LIFE DATES: Not reported

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

acetone

Details on oral exposure:

No information provided

Doses:

Not reported. The authors state rats are given dosages differeing in a ratio of 10.

No. of animals per sex per dose:

6 rats/dose group

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days (or other?); Not reported
- Frequency of observations and weighing: Not reported
- Necropsy of survivors performed: Not reported
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Not reported

Statistics:

Not reported

Results and discussion

Preliminary study:

NA

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

5.84 other: g/kg body weight

Mortality:

Not reported

Clinical signs:

other: other: other: Not reported

Gross pathology:

Not reported

Other findings:

Not reported

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

The work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, these results are deemed reliable.