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Diss Factsheets
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EC number: 215-269-1 | CAS number: 1317-38-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Already evaluated by the Competent Authority for Biocides and Existing Substances Regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Copper oxide
- EC Number:
- 215-269-1
- EC Name:
- Copper oxide
- Cas Number:
- 1317-38-0
- Molecular formula:
- CuO
- IUPAC Name:
- oxocopper
- Details on test material:
- Lot/Batch number: 02-0084
Description: Brown/black powder
Purity: 97.7% cupric oxide
Stability: Stable at room temperature.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Source: David Percival Ltd, Moston, Sandbach, Cheshire, UK.
Sex: Male
Age at study initiation: At the start of the study, the mean bodyweights were reported to be 2-3.5 kg and the ages ranged from 12 - 16 weeks old.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: On the day before the test, the dorsal/flank area was clipped to remove all fur.
- Vehicle:
- water
- Remarks:
- Distilled water.
- Controls:
- other: No, untreated skin areas acted as a control.
- Amount / concentration applied:
- Concentration in vehicle: Not applicable.
Total volume applied: 0.5 g of test material, moistened with distilled water, was placed under a 2.5 cm x 2.5 cm cotton gauze patch and placed on the
shorn skin. - Duration of treatment / exposure:
- Duration of exposure: 4 hours
- Observation period:
- Postexposure period: 72 hours
- Number of animals:
- Number of animals per group: 3.
- Details on study design:
- Preparation of test substance: Test substance was prepared by mixing 0.5 grams of test substance with 0.5 ml of distilled water, immediately before
application.
Removal of test substance: Any residual test material was removed with 74% Industrial Methylated Spirits.
Scoring system: Draize scoring system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
Any other information on results incl. tables
Overall result: There was no evidence of skin irritation noted during the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material did not meet the criteria for classification as irritant or corrosive to skin according to the EU labelling regulations Commission
Directive 93/21/EEC. - Executive summary:
Materials and Methods
This study was conducted to assess the irritancy potential of copper oxide to the skin of the New Zealand White rabbit. A group of 3 male New Zealand White rabbits were given a single, 4-hour, semi-occluded dermal application of copper oxide (0.5 g moistened with 0.5 ml of distilled water) to intact skin clipped free of fur. Irritancy was determined 1, 24, 48 and 72 hours after the test substance was removed.
The study was conducted according to OECD Guidelines for the Testing of Chemicals No. 404 'Acute Dermal Irritation/Corrosion' (adopted 17 July 1992) and Commission Directive 92/69/EEC Method B4 Acute Toxicity (Skin Irritation). The study was also conducted according to GLP.
No deviations from the test guidelines, or deficiencies in the method were reported. Results and DiscussionThe test material produced a primary irritation index of 0.0 and was classified as NON IRRITANT to rabbit skin according to the Draize classification scheme. No corrosive effects were noted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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