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EC number: 203-953-2 | CAS number: 112-27-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See attached justification document 'update_Category Justification_ethylene glycol and higher glycols_2022.doc'
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
See above.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
See above.
3. ANALOGUE APPROACH JUSTIFICATION
See above.
4. DATA MATRIX
See above. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (DOC removal)
- Value:
- 101
- Sampling time:
- 28 d
- Remarks on result:
- other: readily biodegradable, but failing 10-day window
- Remarks:
- CAS 111-46-6, 301A, BASF AG, 1994
- Parameter:
- % degradation (DOC removal)
- Value:
- 99
- Sampling time:
- 28 d
- Remarks on result:
- other: readily biodegradable, but failing 10-day window
- Remarks:
- CAS 111-46-6, 301B, BASF AG, 1995
- Parameter:
- % degradation (DOC removal)
- Value:
- 102
- Sampling time:
- 28 d
- Remarks on result:
- other: readily biodegradable, but failing 10-day window
- Remarks:
- CAS 111-46-6, 301A, BASF AG, 1995
- Parameter:
- % degradation (O2 consumption)
- Value:
- 90
- Sampling time:
- 28 d
- Remarks on result:
- other: inherently biodegradable
- Remarks:
- CAS 111-46-6, 302C, MITI, 1989
- Parameter:
- % degradation (DOC removal)
- Value:
- > 90 - < 100
- Sampling time:
- 20 d
- Remarks on result:
- other: readily biodegradable
- Remarks:
- CAS 112-60-7, 301A, BASF AG, 1995
- Parameter:
- % degradation (DOC removal)
- Value:
- >= 90 - <= 100
- Sampling time:
- 10 d
- Remarks on result:
- other: ready biodegradable, but falling 10-day window
- Remarks:
- CAS 107-21-1, 301A, BASF AG, 1996
- Parameter:
- % degradation (O2 consumption)
- Value:
- >= 83
- Sampling time:
- 14 d
- Remarks on result:
- other: ready biodegradable
- Remarks:
- CAS 107-21-1, 301C, MITI, 1988
Reference
Description of key information
In conclusion, the evaluation of the biodegradability of the five short chain ethylene glycols can be derived from numerous different studies. Summarizing all available data for the structurally similar substances, it can be concluded that the complete members of the group including the 2,2'-(Ethylenedioxy)diethanol are readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
There is no data for assessment of the biodegradability of 2,2'-(Ethylenedioxy)diethanol. Therefore a read-aross approach was performed with three structurally similar substances (CAS 107 -21 -1, CAS 111 -46 -6, CAS 112 -60 -7).
Several results on the ready biodegradability of the diethylene glycol (DEG, CAS 111 -46 -6) are available. According to the available study reports, the substance fulfils the ready biodegradability criteria within the 28-d test period; however, the 10-day window criterion is failed in all of the available studies (301A BASF AG 1995, 1994, 301B BASF AG, 1995). DEG can be assessed as „biodegradable“ or „readily biodegradable, but failing the 10-d window“.
Additionally, the inherent biodegradability of DEG is supported by a OECD 302C study (NITE, 2017).
In case of mono-ethylene glycol (CAS 107 -21 -1) a very rapid biodegradation was detected in the DOC Die Away Test according to OECD 301A (BASF AG, 1996). After 10 days > 90 % degradation of ethylene glycol was determined. The time window of the degradation phase is approx. 3 days.
In a MITI-I test (similar to OECD 301 C) the substance was degraded between 83 and 96% in 14 days of exposure (based on oxygen consumption, BOD/ThOD; MITI, 1988). A mixture of sewage, soil and natural water was used as inoculum. The validity criteria of the OECD guideline 301C were met. In the test study conducted according to OECD 301A tetra-EG (CAS 112 -60 -7) was degraded within a time window of approx. 9 days (BASF, 1995).
In conclusion, the evaluation of the biodegradability of the five short chain ethylene glycols can be derived from numerous different studies. Summarizing all available data for the structurally similar substances, it can be concluded that the complete members of the group including the 2,2'-(Ethylenedioxy)diethanol are readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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