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EC number: 215-204-7 | CAS number: 1313-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-07-05 to 1990-08-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted 24 February 1987
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- The study report states that the study was conducted in compliance with Good Laboratory Practice Standards, e.g. by the United Kingdom Compliance Programme, Department of Health & Social Security 1986 and subsequent revision, Department of Health, 1989.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- disodium molybdate
- IUPAC Name:
- disodium molybdate
- Reference substance name:
- 7631-95-0
- Cas Number:
- 7631-95-0
- IUPAC Name:
- 7631-95-0
- Reference substance name:
- Disodium molybdate
- EC Number:
- 231-551-7
- EC Name:
- Disodium molybdate
- Cas Number:
- 7631-95-0
- Molecular formula:
- Na2MoO4
- IUPAC Name:
- 231-551-7
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): Sodium molybdate
- Physical state: white crystalline powder
- Analytical purity: 98.8 %, calculated based on Molybdenum content of 46.03%
- Impurities (identity and concentrations): no relevant impurities were stated (> 1.0 %).
- Purity test date: 1990-06-06
- Storage condition of test material: at room temperature
No further significant information was stated.
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: approximately 4 to 6 weeks
- Weight at study initiation (main study): weight range of 108 to 140 g
- Fasting period before study: Access to food only was prevented overnight prior to and approximately 4 hours after dosing.
- Housing: housed in groups of up to five rats of the same sex in metal cages with wire mesh floor.
- Diet (ad libitum): standard laboratory rodent diet (SDS LAD 1)
- Water (ad libitum): domestic quality potable water
- Acclimation period: 8 days prior to the start of the main study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): mean daily minimum and maximum temperatures of the animal room were 24 °C and 29°C respectively
- Humidity (%): mean daily relative humidity value was 67% R.H.
- Air changes (per hr): approximately 15 air changes/hour
- Photoperiod (hrs dark / hrs light): 12/12
No further significant information on test animals
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE & DOSAGE PREPARATION
Sodium molybdate was prepared at various (w/v) concentrations in corn oil and administered at a volume of 10 ml/kg bodyweight.
Concentration in vehicle: Dose 1: 32 % w/v; Dose 2: 50 % w/v; Dose 3: 64 % w/v.
MAXIMUM DOSE VOLUME APPLIED: 6400 mg/kg
Preliminary study:
A trial was carried out to establish a dosing regimen for the main study. Groups of two male and two female rats were dosed at 250 and 1000mg/kg bodyweight.
Main study:
The initial dose level was selected on the basis of the preliminary study. Further groups were dosed, after review of the results, to obtain a dose response curve and permit estimation of a median lethal dose.
Treatment procedure:
The appropriate dose volume of the test substance was administered to each rat using a syringe and plastic catheter (8 choke).
No further significant details stated - Doses:
- Preliminary study:
Dose 1: 250 mg/kg
Dose 2: 1000mg/kg
Main study:
Dose 1: 3200 mg/kg
Dose 2: 5000 mg/kg
Dose 3: 6400 mg/kg - No. of animals per sex per dose:
- Preliminary study:
2 males/ 2 females per dose
Main study:
5 males/5 females per dose - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: Preliminary study 5 days and main study 14 days
- Frequency of observations and weighing: Animals were observed soon after dosing and at frequent intervals for the remainder of Day 1 (a minimum period of five hours). On subsequent days the animals surviving treatment were observed once in the morning and again at the end of the experimental day. Clinical signs were recorded at each observation. Individual bodyweights of rats were recorded on Days 1 (day of dosing), 8 and 15 or at death.
Also, the following were recorded on the main study: approximate time of death of individual rats; the nature, severity, approximate time of onset and duration of each toxic sign.
- Necropsy of survivors performed: yes. All surviving animals on the main study were killed on Day 15 by carbon dioxide asphyxiation. All animals that died during the study and those killed on Day 15 were subjected to a macroscopic post mortem examination which consisted of opening the cranial, abdominal and thoracic cavities. The macroscopic appearance of all examined tissues was recorded, and all livers and kidneys were preserved in buffered 10& formalin in order to satisfy any possible future requirement for further examination of these tissues.
No further significant details were stated. - Statistics:
- The acute median lethal oral dose (LD50) to male and female rats was calculated using the method of Finney (1971, Probit Analysis, 3rd Edition, Cambridge University Press).
Separate LD50 values for males and females were estimated by undertaking probit analysis on the mortality data from the preliminary and main studies by fitting two parallel lines to the data (males only and females only) using the technique described by Finney (1978, Statistical Method in Biological Assay, 3rd Edition, Charles Griffin, London). A chi-square test was carried out to check that the data did not contain any evidence of non-parallelism.
Where the slope was not significantly different from zero, approximate confidence limits were calculated by taking the LD 50 estimate given and multiplying and dividing twice by the standard error obtained after adjustment for heterogeneity. The standard errors presented for slopes do not take heterogeneity into account.
Results and discussion
- Preliminary study:
- The results of the preliminary study indicated that the acute median lethal oral dose to male and female rats of Sodium molybdate was greater than 1000 mg/kg bodyweight.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 233 mg/kg bw
- 95% CL:
- >= 2 733 - <= 6 556
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 040 mg/kg bw
- 95% CL:
- >= 1 912 - <= 6 075
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 461 mg/kg bw
- 95% CL:
- >= 2 396 - <= 7 350
- Mortality:
- There were deaths following a single oral dose of Sodium molybdate in 3/5 male and 1/5 female rats dosed at 3200 mg/kg bodyweight, in 1/5 male and 2/5 female rats dosed at 5000 mg/kg, and in 5/5 male and 5/5 female rats dosed at 6400 mg/kg. Deaths occurred from within one hour of dosing until Day 2.
- Clinical signs:
- other: Pilo-erection was observed in all rats within five minutes of dosing and throughout the remainder of Day 1. This sign was accompanied on Day 1 and/or at later intervals by: - abnormal body carriage (hunched posture) in 5/5 males and 5/5 females dosed at 3
- Gross pathology:
- Autopsy of rats that died during the study revealed no macroscopic abnormalities. Terminal autopsy revealed no macroscopic abnormailites.
- Other findings:
- Estimation of LD50 values
Combined sexes:
The slope of the probit line was 4.7 with a standard error of 1.9 using log. transformation of dose. The heterogeneity factor was significant (P<0.025). Consequently, approximate confidence limits were calculated by taking the LD50 estimate and multiplying and dividing twice by the standard error obtained. The confidence limits did not therefore take heterogeneity into account.
Separate sexes:
The slope of the parallel probit lines was 4.8 with a standard error of 2.0 using log. transformation of dose. The heterogeneity factor was not significant.
The difference between the lines for male and female rats was not statistically significant.
The chi-square test for parallelism gave no evidence of non-parallelism.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- (EU)
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