Registration Dossier
Registration Dossier
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EC number: 436-060-3 | CAS number: - FC 84508 PK
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From July 30, 2003 to August 06, 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- < 0.5 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 6.3 - <= 7.3
- Conclusions:
- Under the test conditions, the water solubility of the test substance is determined to be <0.5 µg/L at 20 °C
- Executive summary:
A study was performed to determine the water solubility of test substance according to EU Method A.6 and OECD 105 in compliance with GLP.
The test was performed at 20 °C using Column-Elution-Method.
Under the test conditions, the water solubility of the test substance is determined to be <0.5 µg/L at 20 °C
Reference
Description of key information
Three studies according to OECD 105/ECC A.6 have been conducted. The water solubility of the test substance was reported to be <0.5 µg/L, <0.1 mg/L and < 1mg/L at 20 °C. The test substance is considered highly insoluble.
Key value for chemical safety assessment
Additional information
A study was performed to determine the water solubility of test substance according to EU Method A.6 and OECD 105. The test was performed at 20 °C using Column-Elution-Method. The water solubility of the test substance was determined to be <0.5 µg/L at 20 °C. (Schminke A, 2003)
A study was performed to determine the water solubility of test substance according to EU Method A.6 and OECD 105. In the preliminary test, 2 mg of the test substance could not be dissolved in 200 mL of purified water. Therefore the determination of the water solubility of test substance was performed by the column-elution method at 20 °C. Water solubility of the test substance was determined to be <1 mg/L at 20 °C (Schleich W, 2001)
A study was performed to determine the water solubility of test substance according to EU Method A.6 and OECD 105. In the preliminary test, 2 mg of the test substance could not be dissolved in 200 mL of purified water. Therefore, the determination of the water solubility of test substance was performed by the column-elution method at 20 °C. The water solubility of the test substance was determined to be <0.1 mg/L at 20 °C (Schleich W, 2001)
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