Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-804-9 | CAS number: 99-96-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
p-Hydroxybenzoic acid is considered as not skin sensitising. The substance was not a skin sensitizer in a LLNA assay with young female mice at concentrations of 5, 10 and 25% in dimethylsulfoxide (Honarvar 2009).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
There are no data and no information available which indicates a respiratory sensitisation by p-Hydroxybenzoic acid. There is no further study necessary according to REACH standard data requirements.
Justification for classification or non-classification
p-Hydroxybenzoic acid is considered as not skin sensitising. The substance was not a skin sensitizer in a LLNA assay with young female mice at concentrations of 5, 10 and 25% in dimethylsulfoxide (Honarvar 2009).
There are no data and no information available which indicates a respiratory sensitisation by p-Hydroxybenzoic acid. This is supported by an 11-day repeated dose inhalation study, which revealed no signs for a sensitisation of the respiratory tract (see IUCLID section 7.5.3).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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