Registration Dossier
Registration Dossier
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EC number: 203-961-6 | CAS number: 112-34-5
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original study report not reviewed. Included for completion from a secondary source. Since the paper ruled out the substance as being the cause of the effects seen, further analysis of the study was not deemed necessary.
Data source
Reference
- Reference Type:
- publication
- Title:
- Arbeitsmedizinish-toxikologische Beurteilung von butylglykol und anderen Inhaltsstoffen von Tepetenfarben
- Author:
- Thies Von AM, Hofmann HT, Elschnig G
- Year:
- 1 997
- Bibliographic source:
- Zbl Arbeitsmed 27, 2-6
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: inhalation
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Remarks:
- not applicable
Test material
- Reference substance name:
- 2-(2-butoxyethoxy)ethanol
- EC Number:
- 203-961-6
- EC Name:
- 2-(2-butoxyethoxy)ethanol
- Cas Number:
- 112-34-5
- Molecular formula:
- C8H18O3
- IUPAC Name:
- 2-(2-butoxyethoxy)ethanol
- Details on test material:
- Substance contained in a water based paint.
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 2
- Ethical approval:
- not applicable
- Route of exposure:
- inhalation
- Reason of exposure:
- accidental
- Exposure assessment:
- estimated
Results and discussion
- Clinical signs:
- Nephrotoxicity and hepatotoxicity reported.
Applicant's summary and conclusion
- Conclusions:
- The poisoning incident could not be attributed to exposure to 2-(2-butoxyethoxy)ethanol
- Executive summary:
Two patients reported liver and kidney damage following inhalation absorption of 2 -(2 -butoxyethoxy)ethanol from the use of paint containing the solvent. A detailed investigation of case lead to the conclusion that the reported effects were almost certainly unrelated to solvent exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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