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EC number: 941-364-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Read across justification included in Section 13
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1979-05-22 to 1979-08-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it was conducted according to, or similar to guideline study OECD 420.
- Justification for type of information:
- Read across justification included in Section 13
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: you adults
- Weight at study initiation: 200 to 400 g
- Fasting period before study: feed was withheld overnight prior to dosage
- Housing: housed individually in suspended cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: two weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
IN-LIFE DATES: not reported - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: no vehicle
- Amount of vehicle (if gavage): no vehicle
- Justification for choice of vehicle: no vehicle
- Lot/batch no. (if required): no vehicle
- Purity: no vehicle
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg
DOSAGE PREPARATION (if unusual): not reported
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: N/A - Doses:
- 2.5, 5, 10, 15, and 20 mL/kg
- No. of animals per sex per dose:
- 5 animals/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weight was recorded on days 0, 7, and 14
- Necropsy of survivors performed: yes - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 9 mL/kg bw
- 95% CL:
- >= 5.58 - 14.51
- Remarks on result:
- other: approx 7600 mg/kg bw
- Mortality:
- Mortality rates of the five dose groups (2.5, 2.0, 10, 15, and 20 mL/kg) were 12.5, 20, 70, 40, and 90% respectively.
- Clinical signs:
- other: Clinical signs observed were oily urine stains and oily diarrhoea, which resulted in hair loss, irritation, redness, and sores. In many cases, the anal area had open sores. In the highest dose (20 mL/kg) the entire ventral side and legs were affected. In
- Gross pathology:
- Rats that survived for the duration of the study had few abnormalities and abnormal signs that were observed included enlarges Peyer's patched on the intestine. In both surviving animals and those that died prematurely, many exhibited mild irritation in their lungs or congestion to fluid filled abcesses. In the animals that died prematurely, almost all had intestinal damage including hemorrhaging in the stomach and thinning of the intestinal walls. A few rats has white spots on their caecums and increased gas was noticed in the gastrointestinal tract.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the test material had an oral LD50 of 9.0 mL/kg (approx 7600 mg/kg) body weight. The test material is not classified according to EU criteria.
- Executive summary:
In an acute oral toxicity study, five groups of ten rats (5 males and 5 females) were given a single dose of the appropriate amount of diesel fuel (marketplace sample) (2.5, 5.0, 10, 15, or 20 mL/kg) via oral gavage. Dose levels were chosen to produce expected mortality rates between 10 and 90%. Signs of mortality and toxicity were observed daily for the duration of the study (14 days). Body weight was measured on days 0 and 7, and upon death. Gross necropsy was performed on each animal when they died or by day 14.
Mortality rates of the five dose groups (2.5, 5, 10, 15, 20 mL/kg) were 12.5, 20, 70, 40, and 90% respectively. Signs of toxicity were observed in all dose groups. Severity increased with increased dose. Clinical signs observed were oily urine stains and oily diarrhoea, which resulted in hair loss, irritation, redness, and sores. In many cases, the anal area had open sores. In the highest dose (20 mL/kg) the entire ventral side and legs were affected. In some instances there was blood around the eyes, nose, and mouth. Other symptoms noted included lethargy, pus, or blood at the urinary orifice. Gross pathology observations were also similar in each dose group. In rats who survived for the duration of the study (14 days), there were few abnormalities. In these rats minor observations included enlarged Peyer's patches on intestines. Both animals that died and survived exhibited mild irritation and congestion in the lungs, in addition to fluid-filled abscesses in the lungs. The majority of the animals that died before day 14 showed intestinal damage including, hemorrhaging, thinning of intestinal walls, and increased gas in the gastrointestinal tract.
Under the conditions of this study, the test material had an oral LD50 of 9.0 mL/kg (approx 7600 mg/kg) and a 95% confidence interval of 5.58 and 14.51 mL/kg. the test material was determined to have a median lethal dose according to the study report. The test material is not classified according to EU criteria.
This study received a Klimisch score of 1and is classified as reliable without restriction because it was conducted similar to guideline study OECD 401.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Petroleum gas oil fraction, co-processed with renewable hydrocarbons of plant and/or animal origin
- EC Number:
- 941-364-9
- Molecular formula:
- Not applicable to UVCB substance
- IUPAC Name:
- Petroleum gas oil fraction, co-processed with renewable hydrocarbons of plant and/or animal origin
- Test material form:
- liquid
- Details on test material:
- EC 941-364-9
Reference substance for target in read-across analogue approach
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: you adults
- Weight at study initiation: 200 to 400 g
- Fasting period before study: feed was withheld overnight prior to dosage
- Housing: housed individually in suspended cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: two weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
IN-LIFE DATES: not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: no vehicle
- Amount of vehicle (if gavage): no vehicle
- Justification for choice of vehicle: no vehicle
- Lot/batch no. (if required): no vehicle
- Purity: no vehicle
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg
DOSAGE PREPARATION (if unusual): not reported
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: N/A - Doses:
- 2.5, 5, 10, 15, and 20 mL/kg
- No. of animals per sex per dose:
- 5 animals/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weight was recorded on days 0, 7, and 14
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 9 mL/kg bw
- 95% CL:
- >= 5.58 - <= 14.51
- Remarks on result:
- other: approx 7600 mg/kg bw
- Mortality:
- Mortality rates of the five dose groups (2.5, 2.0, 10, 15, and 20 mL/kg) were 12.5, 20, 70, 40, and 90% respectively.
- Clinical signs:
- other: Clinical signs observed were oily urine stains and oily diarrhoea, which resulted in hair loss, irritation, redness, and sores. In many cases, the anal area had open sores. In the highest dose (20 mL/kg) the entire ventral side and legs were affected. In
- Gross pathology:
- Rats that survived for the duration of the study had few abnormalities and abnormal signs that were observed included enlarges Peyer's patched on the intestine. In both surviving animals and those that died prematurely, many exhibited mild irritation in their lungs or congestion to fluid filled abcesses. In the animals that died prematurely, almost all had intestinal damage including hemorrhaging in the stomach and thinning of the intestinal walls. A few rats has white spots on their caecums and increased gas was noticed in the gastrointestinal tract.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the test material had an oral LD50 of 9.0 mL/kg (approx 7600 mg/kg) body weight. The test material is not classified according to EU criteria.
- Executive summary:
In an acute oral toxicity study, five groups of ten rats (5 males and 5 females) were given a single dose of the appropriate amount of diesel fuel (marketplace sample) (2.5, 5.0, 10, 15, or 20 mL/kg) via oral gavage. Dose levels were chosen to produce expected mortality rates between 10 and 90%. Signs of mortality and toxicity were observed daily for the duration of the study (14 days). Body weight was measured on days 0 and 7, and upon death. Gross necropsy was performed on each animal when they died or by day 14.
Mortality rates of the five dose groups (2.5, 5, 10, 15, 20 mL/kg) were 12.5, 20, 70, 40, and 90% respectively. Signs of toxicity were observed in all dose groups. Severity increased with increased dose. Clinical signs observed were oily urine stains and oily diarrhoea, which resulted in hair loss, irritation, redness, and sores. In many cases, the anal area had open sores. In the highest dose (20 mL/kg) the entire ventral side and legs were affected. In some instances there was blood around the eyes, nose, and mouth. Other symptoms noted included lethargy, pus, or blood at the urinary orifice. Gross pathology observations were also similar in each dose group. In rats who survived for the duration of the study (14 days), there were few abnormalities. In these rats minor observations included enlarged Peyer's patches on intestines. Both animals that died and survived exhibited mild irritation and congestion in the lungs, in addition to fluid-filled abscesses in the lungs. The majority of the animals that died before day 14 showed intestinal damage including, hemorrhaging, thinning of intestinal walls, and increased gas in the gastrointestinal tract.
Under the conditions of this study, the test material had an oral LD50 of 9.0 mL/kg (approx 7600 mg/kg) and a 95% confidence interval of 5.58 and 14.51 mL/kg. the test material was determined to have a median lethal dose according to the study report. The test material is not classified according to EU criteria.
This study received a Klimisch score of 1and is classified as reliable without restriction because it was conducted similar to guideline study OECD 401.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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