Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 274-778-7 | CAS number: 70693-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007-03-06 - 2007-04-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA 850.135
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM E1191-970
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Pentapotassium bis(peroxymonosulphate) bis(sulphate)
- EC Number:
- 274-778-7
- EC Name:
- Pentapotassium bis(peroxymonosulphate) bis(sulphate)
- Cas Number:
- 70693-62-8
- Molecular formula:
- H3K5O18S4
- IUPAC Name:
- pentapotassium bis((hydroperoxysulfonyl)oxidanide) hydrogen sulfate sulfate
- Test material form:
- solid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- not indicated
Test solutions
- Vehicle:
- no
- Details on test solutions:
- not indicated
Test organisms
- Test organisms (species):
- Americamysis bahia (previous name: Mysidopsis bahia)
- Details on test organisms:
- TEST ORGANISM
- Common name: Mysids (Americamysis bahia)
- Source: in-house cultures
- Age of parental stock: < 24 h
- Feeding during test: yes
- Food type: newly hatched brine shrimp nauplii (Artemia) and commercial shrimp feed
- Amount: not reported
- Frequency: at least twice daily
BREEDING METHOD
Adults utilised for reproduction of juvenile test organisms were maintained in ABC saltwater with salinity of 18 to 21‰ and at 26°C. In the definitive test at the time of maturation adult mysids from reproduction retention chambers were paired and placed into another set of cylindrical retention chambers, brood chambers, consisting of a glass Petri dish base with a nylon screen collar.
EXAMINATION / SAMPLING
On a daily basis, dead first generation mysids were counted, identified by gender (if mature), and removed at the time of observation. Any missing mysids were also noted, but counted as dead in data analysis. Adult mysids that became impinged on the retention screens above the water line after day 12 were noted and were excluded fro the initial number of mysids in the percent survival data analyses.Where possible, gender was confirmed upon mortality and at test termination.
HANDLING OF OFFSPRING
At least fifteen juvenile mysids were collected from each test chamber and added to mesh retention chambers and placed back into the test chambers. The survival of these animals was observed over 96 hours
Study design
- Test type:
- flow-through
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 24 d
- Post exposure observation period:
- 72 hours
Test conditions
- Hardness:
- Not reported
- Test temperature:
- 24.5-25.5°C
- pH:
- 7.43 to 7.70
- Dissolved oxygen:
- 5.81 to 7.39 mg/L
- Salinity:
- 20±3‰
- Nominal and measured concentrations:
- Nominal test concentrations: 33.3, 66.7, 133, 267, 533 µg KMPS/L
Nominal concentration of stock solution: 1.870 mg KHSO5/L
Measured concentrations of stock solution: 1.79 – 2.160 mg/L KHSO5/L, (96-116% of nominal)
Results were based on nominal concentrations. - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Size: 32 L
- Aeration: no
- Type of flow-through: using a 2-L proportional equal solvent diluter system
- Renewal rate of test solution: 163 L per day, corresponding to five volume additions per 24-h period, or cycle rate of 10 cycles/hour
- No. of organisms per vessel: 30 (15 mysids per retention chamber)
- No. of vessels per concentration (replicates): 3
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: commercial sea salt mix and laboratory fresh water consisting of well water that was demineralised by reverse osmosis
- Total organic carbon: Not reported
- Ca/Mg ratio: not reported
- Conductivity: not reported
- Salinity: 20±3‰
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 14 h photoperiod daily
- Light intensity: wide spectrum fluorescents bulbs, 407 to 428 lux
EFFECT PARAMETERS MEASURED: Survival, growth, reproduction
VEHICLE CONTROL PERFORMED: no
RANGE-FINDING STUDY
- Test concentrations: 0, 0.111, 0.222, 0.444, 0.889. 1.78, 3.33 mg KMPS/L
- Results used to determine the conditions for the definitive study:
The mean % survival was 90, 93, 90, 0, 0, 0 and 0% in the 0, 0.111, 0.222, 0.444, 0.889. 1.78, 3.33 mg KMPS/L treatments, respectively.
Mean total lengths were 5.1, 5.2 and 4.9 mm in the 0, 0.111, 0.222 KMPS/L treatments, respectively. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 267 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: survival
- Duration:
- 28 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 533 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: survival
- Duration:
- 28 d
- Dose descriptor:
- LC50
- Effect conc.:
- 367 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: survival
- Remarks on result:
- other: 358 to 378
- Duration:
- 28 d
- Dose descriptor:
- other: MATC (Maximum acceptable toxicant concentration)
- Effect conc.:
- 378 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other:
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 267 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: juvenile survival
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 267 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: juvenile survival
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 267 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: length
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 267 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: length
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 267 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: young per female
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 267 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: young per female
- Details on results:
- Details are given under "Remarks on results including tables and figures"
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- SAS software, NOEC Fisher´s exact test, ANOVA, one-tailed Dunnett´s test were used.
Any other information on results incl. tables
Effects on first generation survival (%)
Nominal concentration (µg KMPS triple salt/L) | Day 7 | Day 14 | Day 21 | Day 28 |
0 | 100 | 96 | 95 | 93 |
33.3 | 100 | 99 | 97 | 95 |
66.7 | 100 | 100 | 99 | 98 |
133 | 100 | 100 | 100 | 99 |
267 | 97 | 97 | 94 | 92 |
533 | 0 | 0 | 0 | 0* |
*statistically significant reduction compared to control (Fisher´s test, p= 0.05)
Effects on second generation survival
Nominal concentration (µg KMPS triple salt/L) | Day 0 (Initial No. of animals) | Day 4 (No. of live animals) | Mean survival (%) |
0 | 16 | 14 | 91 |
33.3 | 19 | 18 | 95 |
66.7 | 20 | 19 | 95 |
133 | 18 | 17 | 94 |
267 | 17 | 16 | 98 |
533 | - | - | - |
Effects on length (mm)
Nominal concentration (µg KMPS triple salt/L) | male | female | ||
Day 14 | Day 28 | Day 14 | Day 28 | |
0 | 5.23 (0.0643) | 6.06 (0.166) | 5.46 (0.0) | 5.90 (0.121) |
33.3 | 5.05 (0.310) | 5.84 (0.111) | 5.22 (0.399) | 5.87 (0.325) |
66.7 | 5.31 (0.0954) | 6.20 (0.284) | 5.25 (0.205) | 6.12 (0.132) |
133 | 5.36 (0.139) | 6.48 (0.227) | 5.27 (0.162) | 6.34 (0.203) |
267 | 5.12 (0.250) | 6.00 (0.236) | 5.43 (0.0503) | 6.27 (0.0742) |
533 | - | - | - | - |
Values in parenthesis represent standard deviation
Effects on reproduction
Nominal concentration (µg KMPS triple salt/L) | Mysid reproduction | |
No. young/female | Young/female with at least two broods | |
0 | 12.2 (4.39) | 14.0 (5.02) |
33.3 | 15.9 (1.80) | 17.4 (3.27) |
66.7 | 19.2 (4.37) | 21.0 (5.96) |
133 | 18.2 (3.56) | 19.0 (3.36) |
267 | 15.0 (4.50) | 16.2 (3.36) |
533 | - | - |
Values in parenthesis represent standard deviation
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- (Mortality of parent animals < 20% at test termination)
- Conclusions:
- The study and the conclusions which are drawn from it fulfill the quality criteria (validity, reliability, repeatability). No clear dose-response relationship was observed, however, at the highest concentration significant effects occurred. The NOEC was similar for all parameters and was determined to be 267 µg KMPS triple salt/L.
Due to limited analytical method, only the stock solution was analysed for KHSO5. Results are based on nominal concentrations. - Executive summary:
Materials and methods
The potential of KMPS triple salt for acute and chronic effects on saltwater mysids (Americamysis bahia) exposed for 28 days in a life-cycle test was investigated according to the US EPA guideline no. 850.1350 under flow-through conditions. Toxicological endpoints were survival, growth and reproduction.
Results and discussion
After 28 days of exposure mean survival of the first generation mysids were 93, 95, 98, 99, 92 and 0% in the control, 33.3, 66.7, 133, 267 and 533 µgKMPS triple salt/L treatments, respectively, with statistically significant reduction at the highest concentration. The 96-h survival of juvenile mysids was not satistically significant different compared to the control in all treatments. The total young per female was not statistically significant different from the control at any treatment. The second brood was not statistically significant compared to the control.
NOEC = 267 µg KMPS triple salt/L adult and juvenile survival, adult body length, offspring per female
LOEC = 533 µg KMPS triple salt/L adult survival, > 267 µg KMPS triple salt/L juvenile survival, adult body length, offspring per female
EC50 (adult survival) = 367 µg KMPS triple salt/L with a 95% confidence interval of 358 to 378 µg KMPS triple salt/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.