Registration Dossier
Registration Dossier
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EC number: 205-769-8 | CAS number: 150-76-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Very few information are available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data.
- GLP compliance:
- no
Test material
- Reference substance name:
- Mequinol
- EC Number:
- 205-769-8
- EC Name:
- Mequinol
- Cas Number:
- 150-76-5
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 4-methoxyphenol
- Details on test material:
- 4-Methoxyphenol. No other information available.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- other: propylene glycol
- Controls:
- not specified
- Amount / concentration applied:
- undiluted
other: no data. - Details on study design:
- Comment: other: unwashed and washed with water.
Results and discussion
Any other information on results incl. tables
table of results:
| Material | treatment | observations |
| Undiluted | unwashed | slight pain, mod. conjunctivitis, corneal damage and slight iritis essantially subsided in 1 week |
| Undiluted | washed with water | Same as above except completely subsided in 1 week. |
| 10% in PG | washed & unwashed | Mod. pain and slight conjunctivitis subsided in 1 hour. |
Applicant's summary and conclusion
- Interpretation of results:
- other: In view of the results of this assay, no conclusion can be drawn concerning the classification of 4-methoxyphenol.
- Remarks:
- PMP is however officially classified, according to the EU CLP Regulation (EC) n°1272/2008 (eye irritant category 2).
- Conclusions:
- In view of the results of this assay, no conclusion can be drawn concerning the classification of 4-methoxyphenol.
PMP is however officially classified, according to the EU CLP Regulation (EC) n°1272/2008 (eye irritant category 2).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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