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Diss Factsheets
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EC number: 239-854-6 | CAS number: 15763-76-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- No original study report available, not to GLP, no analytical analysis of test concentrations, limited information available from secondary sources, the data produced is thought to be insufficient to statistically derive a NOEC
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: UBA Verlaengerter Toxizitaetstest bei Daphnia magna nach UBA (1984 standard)
- Version / remarks:
- 1984 standard
- Deviations:
- yes
- Remarks:
- Unable to compare to test guidelines, however no analytical confirmation of test chemicals is included
- GLP compliance:
- no
- Remarks:
- Stated that the study was conducted in 1987 without formal GLP, however the laboratory received GLP accreditation in 1989/1990
- Specific details on test material used for the study:
- CAS no: 28348-53-0No further details provided
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Details on test solutions:
- No further details provided
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- No further details provided
- Test type:
- not specified
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 21 d
- Post exposure observation period:
- Not included
- Hardness:
- No details provided
- Test temperature:
- No details provided
- pH:
- No details provided
- Dissolved oxygen:
- No details provided
- Salinity:
- No details provided
- Conductivity:
- No details provided
- Nominal and measured concentrations:
- Nominal concentrations: 30, 100 and 300 mg/L active ingredient
- Details on test conditions:
- No further details provided on the test conditions.
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 30 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- reproduction
- Remarks:
- number of offspring
- Remarks on result:
- other:
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 154 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- reproduction
- Remarks:
- number of offspring
- Details on results:
- For the NOEC for reproduction, there is some discrepancy between the value provided in each of the 3 literature sources. Greim et al (1994) state a NOEC of > 30 mg/L, however the HULS AG document states a NOEC of < 30 mg/L and the HERA Hydrotopes September 2005 document considers a NOEC of > 30mg/L an error based on the data, however the NOEC is most likely to be <30mg/L or 30mg/L. Further details are provided below based on the evaluation of the data provided in the HERA Hydrotopes document.For the NOEC for reproduction, it is indicated the HERA Hydrotropes September 2005 literature source, that the NIOEC relates to the number of offspring produced during the study period. None of the literature sources include the raw data, however this report states 'the average number of offspring produced per day was 43 in the controls, 38 at 30 mg/L, 29 at 100 mg/L and 13 at 300 mg/L, which equate to 88% of control, 67% of control and 30% of control at 30, 100 and 300 mg/L respectively'. There is not considered sufficient data to be able to establish a statistically derived NOEC and it is uncertain whether 88% of the control is a significant
- Results with reference substance (positive control):
- Not applicable
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The long term chronic NOEC for reproductive output in Daphnia magna is <30 mg/L, equal to or >30 mg/L. The LC50 for reproduction is 154 mg/L.
- Executive summary:
A long term chronic study was carried out on Daphnia magna, to determine the potential effects of sodium cumene sulfonate on reproduction. The study was carried out according to the UBA Verlaengerter Toxizitaetstest bei Daphnia magna nach UBA (1984 standard), however it has not been possible to compare the study details with these guidelines. The study was not conducted according to GLP. Details on the study have been compiled based on three information sources (two secondary literature sources and one publication), however details on the study conditions, methodology and results is lacking and based on this the study is considered a reliability klimisch 4 rating.
The available information indicate Daphnia magna were exposed to the test substance for 21 days, at three nominal concentrations of 30, 100 and 300 mg/L in addition to controls. No further details are provided on the test set up. No increased mortality was observed in the Daphnia magna adults, however a decrease in the number of offspring produced was noted at all test concentrations.
The HERA Hydrotopes document states 'the average number of offspring produced per day was 43 in the controls, 38 at 30 mg/L, 29 at 100 mg/L and 13 at 300 mg/L, which equate to 88% of control, 67% of control and 30% of control at 30, 100 and 300 mg/L respectively. Discrepancies exist in the 3 literature sources between the exact NOEC value and one of the reports state the available information is considered insufficient to be able to establish a statistically derived NOEC and it is uncertain whether the 88% reduced reproductive output compared to the control observed in the 30mg/L concentration, is a significant reduction. However, based on a worst case scenario, it is assumed the NOEC is <30 mg/L and the LC50 is 154 mg/L.
Reference
Description of key information
The HYDROTOPES Category comprises the following 6 substances:
STS - Sodium toluene sulphonate (CAS 657-84-1, EC 211-522-5)
SXS - Sodium (xylenes and 4-ethylbenzene) sulphonate (EC 701-037-1)
NH4XS - Ammonium (xylenes and 4-ethylbenzene) sulphonate (EC 943-024-5)
SCS - Sodium cumene sulphonate (CAS 15763-76-5, EC 239-854-6)
KCS - Potassium cumene sulphonate (CAS 164524-02-1, EC 629-764-9)
NH4CS - Ammonium cumene sulphonate (CAS 37475-88-0, 253-519-1)
In addition CaXS (Calcium Xylenesulphonate, CAS 28088-63-3, EC248-829-9)was evaluated for complete the assessment despite it is not registered under REACH.
An environmental risk assessment has indicated that the members of the Hydrotropes category do not pose a risk to the aquatic environment for all relevant uses. In Annex IX of Regulation (EC) No 1907/2006 it is laid down that chronic toxicity tests shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further. There are availbale acute tests on the three hydrotropes subgroups (toluene, xylene and cumene) which did not show any concern for all the three thropic levels. Since the chronic testing would not change the outcome of the environmental risk assessment the additional chronic testing on aquatic invertebrates appears to be unjustified. One chronic test on invertebrates is reported in literature (Huls, 1987), but is considered of poor reliability (Klimisch 4). The study indicates a long term chronic toxicity of sodium cumene sulfonate to Daphnia magna of a NOEC of <30 or 30 mg/L and an LC50 of 154 mg/L. Use of these data, would not change the outcome of the environmental risk assessment and are provided for completeness only. As acute toxicity was not observed at the concentrations tested in the acute studies and the hydrotrope category members are readily biodegradable, no additional chronic testing on aquatic invertebrates is required and this endpoint is waived.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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