Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-104-4 | CAS number: 25564-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a reliable study, the acute oral toxicity test of Pentyl Cyclopentenone FAB was determined to be between 2.0 and 5.0 mL/kg bw. No acute dermal or inhalation studies were available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- This test is performed for each suspected low toxic material to determine an appropriate order of toxicity using five male and five female animals. The most relevant dose-level for the class of substance is selected, and three male and three female animals are dosed at this level. Two groups of one male and one female are dosed above and below this level.
Modification of Standard: Range finding determination only - GLP compliance:
- no
- Remarks:
- (The study pre-dated the introduction of GLP in the UK)
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- other: mice
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Oral intubation 4-5 week old mice were tested. The animals are placed in individual cages, fasted for four hours and then the animals are individually weighed and intubated with the appropriate volumes of the test material. Each animal on one dosage level receives the same amount per kg body weight.
4 week old rats or mice are usually used for these tests, in which it is possible to intubate a maximum dosage of 100 mL/kg. - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Maximum dosage volume applied: 100 ml/kg
- Doses:
- Dose-levels selected for testing:
10.0 mL/kg body weight
5.0 mL/kg body weight
2.0 mL/kg body weight - No. of animals per sex per dose:
- 10.0 mL/kg body weight - 2 animals treated
5.0 mL/kg body weight - 6 animals treated
2.0 mL/kg body weight - 2 animals treated - Control animals:
- not specified
- Details on study design:
- Oral intubation 4-5 week old mice were tested. Groups of mice were intubated at 3 dose levels using graded volumes of the test substance. Animals were observed for up to 7 days after intubation. All animals were autopsied. All survivors were killed and examined post mortem after 7 days.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 - 5 mL/kg bw
- Based on:
- test mat.
- Mortality:
- One mouse dosed at 5 mL/kg died within 30 mins after intubation. All mice were hypothermic within 1 hour after treatment and within 2 hours both mice doesed at 10 mL/kg and three mice dosed at 5 mL/kg had died. The two remaining mice dosed at 5 mL/kg were found dead after 18 and 42 hours respectively. The mice dosed at 2 mL/kg recovered within 18 hours after treatment.
- Clinical signs:
- other: Mice dosed at all three levels were comatose or semi-comatose, cyanosed and exhibiting laboured breathing within 30 mins after treatment.
- Gross pathology:
- Autopsy of the animals that died reveealed slight iritation of the stomach and duodenum with orange fluid present in the duodenum. These mice had pale kidneys and very pale livers.
- Interpretation of results:
- Toxicity Category V
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The acute toxicity of 2-Pentylcyclopent-2-enone was determined to be between 2 and 5 mL/kg body weight.
- Executive summary:
In an acute oral toxicity study, conducted prior to the introduction of GLP or the applicable OECD test guideline, undiluted 2-Pentylcyclopent-2-enone, a group of mice were administered three doses. Animals were observed for clinical signs of toxicity for 7 days and all survivors were examined for gross pathological changes.
One mouse dosed at 5 mL/kg died within 30 mins after intubation. All mice were hypothermic within 1 hour after treatment and within 2 hours both mice doesed at 10 mL/kg and three mice dosed at 5 mL/kg had died. The two remaining mice dosed at 5 mL/kg were found dead after 18 and 42 hours respectively. The mice dosed at 2 mL/kg recovered within 18 hours after treatment.
From the results of this study, the acute oral LD50 of 2-Pentylcyclopent-2-enone in mice was determined to be beetween 2 and 5 mL/kg body weight. Therefore no classification is required under CLP.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Acceptable
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Based on the results of the acute toxicity study in laboratory animals, classification under EU DSD or CLP regulations as acutely toxic by the oral route is not required.
Justification for selection of acute toxicity – oral endpoint
Reliable in vivo study.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.