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Diss Factsheets
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EC number: 203-643-7 | CAS number: 109-06-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information from review article or other reference text.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Metabolism in the rat of some pyrazine derivatives having flavour importance in foods
- Author:
- Hawksworth G. and R.R. Scheline
- Year:
- 1 975
- Bibliographic source:
- Xenobiotica 5, 389-399, cited in EFSA Journal 2013;11(11):3453
- Reference Type:
- review article or handbook
- Title:
- SCIENTIFIC OPINION Scientific opinion on Flavouring Group Evaluation 24, Revision 2 (FGE.24Rev2): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28
- Author:
- European Food Safety Authority (EFSA)
- Year:
- 2 013
- Bibliographic source:
- EFSA Journal 2013;11(11):3453
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Male Wistar rats received a dose of 100 mg/kg by gavage. Urine (24 and 48 h) and bile-samples (5 and 10 h) were collected. Metabolites were extracted and determined by gas chromatography and mass spectrometry.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylpyridine
- EC Number:
- 203-643-7
- EC Name:
- 2-methylpyridine
- Cas Number:
- 109-06-8
- Molecular formula:
- C6H7N
- IUPAC Name:
- 2-methylpyridine
- Details on test material:
- - Name of test material (as cited in study report): 2-methylpyridine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- Single dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw
- Control animals:
- not specified
- Details on dosing and sampling:
- Urine (24 and 48 h) and bile-samples (5 and 10 h) were collected. Metabolites were extracted and determined by gas chromatography and mass spectrometry.
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- Ninety-six per cent of the 100 mg/kg bw dose was excreted as the glycine conjugate, pyridine-2-carboxylic acid (picolinic acid) within 24 hours. No N-oxidation of 2-methylpyridine was observed with a detection limit of the metabolite at 1 % of the dose.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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