Registration Dossier
Registration Dossier
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EC number: 203-643-7 | CAS number: 109-06-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information from review article or other reference text.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Metabolism in the rat of some pyrazine derivatives having flavour importance in foods
- Author:
- Hawksworth G. and R.R. Scheline
- Year:
- 1 975
- Bibliographic source:
- Xenobiotica 5, 389-399, cited in EFSA Journal 2013;11(11):3453
- Reference Type:
- review article or handbook
- Title:
- SCIENTIFIC OPINION Scientific opinion on Flavouring Group Evaluation 24, Revision 2 (FGE.24Rev2): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28
- Author:
- European Food Safety Authority (EFSA)
- Year:
- 2 013
- Bibliographic source:
- EFSA Journal 2013;11(11):3453
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Male Wistar rats received a dose of 100 mg/kg by gavage. Urine (24 and 48 h) and bile-samples (5 and 10 h) were collected. Metabolites were extracted and determined by gas chromatography and mass spectrometry.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylpyridine
- EC Number:
- 203-643-7
- EC Name:
- 2-methylpyridine
- Cas Number:
- 109-06-8
- Molecular formula:
- C6H7N
- IUPAC Name:
- 2-methylpyridine
- Details on test material:
- - Name of test material (as cited in study report): 2-methylpyridine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- Single dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw
- Control animals:
- not specified
- Details on dosing and sampling:
- Urine (24 and 48 h) and bile-samples (5 and 10 h) were collected. Metabolites were extracted and determined by gas chromatography and mass spectrometry.
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- Ninety-six per cent of the 100 mg/kg bw dose was excreted as the glycine conjugate, pyridine-2-carboxylic acid (picolinic acid) within 24 hours. No N-oxidation of 2-methylpyridine was observed with a detection limit of the metabolite at 1 % of the dose.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
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